This paper presents a rational workflow for developing enabling formulations, such as
amorphous solid dispersions, via hot-melt extrusion in less than a year. First, our approach …

Purpose To understand how surfactants affect drug release from ternary amorphous solid
dispersions (ASDs), and to investigate different mechanisms of release enhancement …

Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

Amorphous solid dispersions (ASDs) are a widely used formulation technology for poorly
water-soluble active pharmaceutical ingredients (API). Depending on the API-polymer …

Novel polymeric carriers for amorphous solid dispersions (ASDs) are highly demanded in
pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates …

Amorphous solid dispersions (ASDs), where an active pharmaceutical ingredient (API) is
dissolved in a polymer, are a favored formulation technique to achieve sufficient …

Polymers like poly (vinylpyrrolidone-co-vinyl acetate)(PVPVA) or hydroxypropyl
methylcellulose acetate succinate (HPMCAS) are commonly used as a matrix for amorphous …

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …

The majority of all newly identified active pharmaceutical ingredients (APIs) have a low
solubility in water (partly smaller than marble). In order to enhance their solubility and …

Amorphous solid dispersion (ASD) is one of the most promising enabling formulations
featuring significant water solubility and bioavailability enhancements for biopharmaceutical …