Leukapheresis and hyperleukocytosis, past and future

D Zhang, Y Zhu, Y Jin, NM Kaweme… - International Journal of …, 2021 - Taylor & Francis
Hyperleukocytosis is a hematologic crisis caused by excessive proliferation of leukemic cells
and has a relatively high early mortality due to a series of severe complications. Therefore …

Blood apheresis technologies–a critical review on challenges towards efficient blood separation and treatment

CJO Bacal, JW Maina, HH Nandurkar, M Khaleel… - Materials …, 2021 - pubs.rsc.org
Blood apheresis technologies are crucial during blood donation and toxin removal. Current
purification methods such as leukocytapheresis, erythrocytapheresis, thrombocytapheresis …

Detection of Circulating Tumor Cells in the Diagnostic Leukapheresis Product of Non-Small-Cell Lung Cancer Patients Comparing CellSearch® and ISET

M Tamminga, KC Andree, TJN Hiltermann, M Jayat… - Cancers, 2020 - mdpi.com
Circulating tumor cells (CTCs) detected by CellSearch are prognostic in non-small-cell lung
cancer (NSCLC), but rarely found. CTCs can be extracted from the blood together with …

A novel predictive algorithm to personalize autologous T-cell harvest for chimeric antigen receptor T-cell manufacture

MA O'Reilly, A Malhi, KPL Cheok, S Ings, C Balsa… - Cytotherapy, 2023 - Elsevier
Background aims The most widely accepted starting materials for chimeric antigen receptor
T-cell manufacture are autologous CD3+ T cells obtained via the process of leukapheresis …

Current state of apheresis technology and its applications

RW Maitta - Transfusion and Apheresis Science, 2018 - Elsevier
Apheresis is at the forefront of therapeutic approaches for an increasing number of
indications caused by formation of pathologic antibodies treated by therapeutic plasma …

Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival

M Tamminga, KC Andree, H van den Bos… - British journal of …, 2022 - nature.com
Abstract Background Circulating tumour cells (CTCs) can be used to monitor cancer
longitudinally, but their use in non-small cell lung cancer (NSCLC) is limited due to low …

Impact of mobilization strategies on peripheral blood stem cell collection efficiency and product quality: a retrospective single-center study

P Rajsp, M Branka, N Besson, A Tanzmann, N Worel - Cancers, 2022 - mdpi.com
Simple Summary We retrospectively reviewed data from cancer patients undergoing
peripheral blood stem cell (PBSC) collection following different mobilization regimens (with …

Advances in biomarker detection: Alternative approaches for blood-based biomarker detection

M Rosado, R Silva, MG Bexiga, JG Jones… - Advances in clinical …, 2019 - Elsevier
In the clinical setting, a blood sample is typically the starting point for biomarker search and
discovery. Mass spectrometry (MS) is a highly sensitive and informative method for …

Get off on the right foot: how to plan an efficient leukocytapheresis to collect T cells for CAR T-cell manufacturing

JA Piñeyroa, J Cid, M Lozano - Transfusion Medicine and Hemotherapy, 2023 - karger.com
Background: The major drug regulatory agencies have approved chimeric antigen receptor
(CAR) T cells for the treatment of some B-cell lymphoproliferative diseases. Their use is …

Generation of alloreactivity-reduced donor lymphocyte products retaining memory function by fully automatic depletion of CD45RA-positive cells

N Müller, K Landwehr, K Langeveld, J Stenzel… - Cytotherapy, 2018 - Elsevier
Background aims For patients needing allogeneic stem cell transplantation but lacking a
major histocompatibility complex (MHC)-matched donor, haplo-identical (family) donors may …