Cutaneous T cell lymphoma

R Dummer, MH Vermeer, JJ Scarisbrick… - Nature Reviews …, 2021 - nature.com
Primary cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphomas
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …

Obesity as a risk factor for COVID-19: an overview

RW Alberca, LM Oliveira, ACCC Branco… - Critical reviews in …, 2021 - Taylor & Francis
The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for
health-care systems worldwide. Many different risk factors are associated with disease …

[HTML][HTML] Mycosis fungoides and Sézary syndrome: clinical presentation, diagnosis, staging, and therapeutic management

D Miyashiro, JA Sanches - Frontiers in oncology, 2023 - frontiersin.org
Mycosis fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas. MF is
the most common cutaneous lymphoma, and it is classified into classic Alibert-Bazin MF …

The role of dipeptidyl peptidase‐4 in cutaneous disease

PM Patel, VA Jones, K Kridin… - Experimental …, 2021 - Wiley Online Library
Abstract Dipeptidyl peptidase‐4 (DPP4) is a multifunctional, transmembrane glycoprotein
present on the cell surface of various tissues. It is present in multiple molecular forms …

[HTML][HTML] Pathogenesis and therapy of primary cutaneous T-cell lymphoma: Collegium Internationale Allergologicum (CIA) update 2020

M Bobrowicz, C Fassnacht, D Ignatova… - International archives of …, 2020 - karger.com
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous disease group of unknown etiology
with a complex immunological background. As CTCL arises from T cells that have a vital role …

[HTML][HTML] Cancer-associated fibroblasts in mycosis fungoides promote tumor cell migration and drug resistance through CXCL12/CXCR4

A Aronovich, L Moyal, B Gorovitz, I Amitay-Laish… - Journal of Investigative …, 2021 - Elsevier
Cancer cells are known to reprogram normal fibroblasts into cancer-associated fibroblasts
(CAFs) to act as tumor supporters. The presence and role of CAFs in mycosis fungoides …

The immunopathogenesis and immunotherapy of cutaneous T cell lymphoma: Pathways and targets for immune restoration and tumor eradication

JS Durgin, DM Weiner, M Wysocka, AH Rook - Journal of the American …, 2021 - Elsevier
Cutaneous T cell lymphomas (CTCLs) are malignancies of skin-trafficking T cells. Patients
with advanced CTCL manifest immune dysfunction that predisposes to infection and …

[HTML][HTML] Imbalanced IL-1B and IL-18 expression in Sezary Syndrome

KCG Manfrere, MP Torrealba, FM Ferreira… - International journal of …, 2023 - mdpi.com
Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an
abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key …

Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation

I Saulite, D Ignatova, YT Chang, C Fassnacht… - …, 2020 - Taylor & Francis
ABSTRACT Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell
lymphoma (L-CTCL) that arises from malignant clonally derived skin-homing CD4+ T cells …

[HTML][HTML] The serine protease CD26/DPP4 in non-transformed and malignant T Cells

G Chitadze, U Wehkamp, O Janssen, M Brüggemann… - Cancers, 2021 - mdpi.com
Simple Summary The transmembrane serine protease CD26/Dipeptidylpeptidase 4
modulates T-cell activation, proliferation, and effector function. Due to their remarkable …