Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics

S Li, J Shi, H Tang - Cell Biology And Toxicology, 2022 - Springer
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
progressive loss of pulmonary function. Drug-induced interstitial lung disease has been …

Antioxidants as potential therapeutics for lung fibrosis

BJ Day - Antioxidants & redox signaling, 2008 - liebertpub.com
Interstitial lung disease encompasses a large group of chronic lung disorders associated
with excessive tissue remodeling, scarring, and fibrosis. The evidence of a redox imbalance …

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

JF Waring, RA Jolly, R Ciurlionis, PY Lum… - Toxicology and applied …, 2001 - Elsevier
Microarray technology, which allows one to quantitate the expression of thousands of genes
simultaneously, has begun to have a major impact on many different areas of drug discovery …

Protective effects of curcumin against amiodarone‐induced pulmonary fibrosis in rats

D Punithavathi, N Venkatesan… - British journal of …, 2003 - Wiley Online Library
We have studied whether curcumin prevents amiodarone‐induced lung fibrosis in rats.
Intratracheal instillation of amiodarone (6.25 mg kg− 1 on days 0 and 2, and then killed on …

A Mechanistic Study on the Amiodarone‐Induced Pulmonary Toxicity

B Al-Shammari, M Khalifa, SA Bakheet… - … medicine and cellular …, 2016 - Wiley Online Library
Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

Adipose tissue–derived mesenchymal stem cells protect against amiodarone-induced lung injury in rats

SM Radwan, D Ghoneim, M Salem, M Saeed… - Applied Biochemistry …, 2020 - Springer
Pulmonary fibrosis (PF) is a progressive and irreversible lung disease, characterized by
poor prognosis with limited treatment options. Mesenchymal stem cells (MSCs) are multi …

Modulation of cytokines and chemokines expression by NAC in cadmium chloride treated human lung cells

CO Odewumi, LM Latinwo, ML Ruden… - Environmental …, 2016 - Wiley Online Library
Cadmium (Cd), is one of the most hazardous metals found in the environment. Cd exposure
through inhalation has been linked to various diseases in lungs. It was shown that Cd …

Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-β1 gene expression but not …

JW Card, WJ Racz, JF Brien, TE Massey - Journal of Pharmacology and …, 2003 - ASPET
Amiodarone (AM) is an efficacious antidysrhythmic agent that can cause numerous adverse
effects, including potentially life-threatening pulmonary fibrosis. The current study was …

Insulin‐like growth factor‐1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone‐induced oxidative injury

R Liao, F Yan, Z Zeng, H Wang, K Qiu… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose Amiodarone is one of the most effective anti‐arrhythmic drugs
available, but its clinical applications are limited by toxic side effects including optic toxicity …

High-dose N-acetylcysteine decreases silica-induced lung fibrosis in the rat

H Zhang, G Yin, H Jiang… - Journal of international …, 2013 - journals.sagepub.com
Objective To study the potential of high-dose N-acetylcysteine (NAC) to attenuate silica-
induced pulmonary fibrosis in the rat. Methods Rats exposed to intratracheal instillation of …