A guide to antigen processing and presentation
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
[HTML][HTML] Multidrug resistance (MDR): A widespread phenomenon in pharmacological therapies
A Catalano, D Iacopetta, J Ceramella, D Scumaci… - Molecules, 2022 - mdpi.com
Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …
Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …
organisms are diverse in function, energization, and structural organization. They form …
Structural and functional diversity calls for a new classification of ABC transporters
C Thomas, SG Aller, K Beis, EP Carpenter… - FEBS …, 2020 - Wiley Online Library
Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad
spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in …
spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in …
Physiological functions of bacterial “multidrug” efflux pumps
PJF Henderson, C Maher, LDH Elbourne… - Chemical …, 2021 - ACS Publications
Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …
pathogenesis because they help bacteria protect themselves against the antimicrobials …
The human ATP‐binding cassette (ABC) transporter superfamily
M Dean, K Moitra, R Allikmets - Human mutation, 2022 - Wiley Online Library
The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that
efflux various substrates across extra‐and intracellular membranes. Mutations in ABC genes …
efflux various substrates across extra‐and intracellular membranes. Mutations in ABC genes …
[HTML][HTML] Current strategies to enhance delivery of drugs across the blood–brain barrier
RI Teleanu, MD Preda, AG Niculescu, O Vladâcenco… - Pharmaceutics, 2022 - mdpi.com
The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …
[HTML][HTML] ABC transporters: human disease and pharmacotherapeutic potential
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are a 48-member
superfamily of membrane proteins that actively transport a variety of biological substrates …
superfamily of membrane proteins that actively transport a variety of biological substrates …
The role of non-coding RNAs in ABC transporters regulation and their clinical implications of multidrug resistance in cancer
Y Wang, Y Wang, Z Qin, S Cai, L Yu… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Multi-drug resistance (MDR) is a hindrance toward the successful treatment of
cancers. The primary mechanism that gives rise to acquired chemoresistance is the …
cancers. The primary mechanism that gives rise to acquired chemoresistance is the …
Molecular basis of cholesterol efflux via ABCG subfamily transporters
The ABCG1 homodimer (G1) and ABCG5–ABCG8 heterodimer (G5G8), two members of the
adenosine triphosphate (ATP)–binding cassette (ABC) transporter G family, are required for …
adenosine triphosphate (ATP)–binding cassette (ABC) transporter G family, are required for …