Drug development consumes huge amounts of time and money and the search for novel
analgesics, which are urgently required, is particularly difficult, having resulted in many …

The number of approved new molecular entity drugs has been decreasing as the
pharmaceutical company investment in research and development is increasing. As we face …

They sought it with thimbles, they sought it with care; They pursued it with forks and hope;
They threatened its life with a railway-share; They charmed it with smiles and soap.(Lewis …

Hydrogen sulfide (H 2 S) is a gasotransmitter endogenously generated from the metabolism
of l-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and …

ABSTRACT Preclinical Research The aim of this study was to evaluate fosinopril‐induced
changes in hemodynamic parameters and tactile allodynia in a rat model of diabetes …

Angiotensins (Angs) modulate blood pressure, hydro-electrolyte composition, and
antinociception. Although Ang (5–8) has generally been considered to be inactive, we show …

A polineuropatia diabética distal é a complicação crônica mais comum do diabetes mellitus,
repercutindo na qualidade de vida dos pacientes. A metformina é um fármaco amplamente …