The timely reconstitution and regain of function of a donor-derived immune system is of
utmost importance for the recovery and long-term survival of patients after allogeneic …

Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune
diseases. TLS present features of secondary lymphoid organs such as segregated T and B …

In humans, different B-cell subpopulations can be distinguished in peripheral bloodand
other tissues on the basis of differential expression of various surface markers. These …

B cells generate antibodies that are essential for immune protection, but their subgroups are
poorly defined. Here, we perform undirected deep profiling of B cells in matched human …

Mouse splenic marginal zone precursors (MZPs) differentiate into marginal zone B (MZB)
cells under a signaling pathway involving Notch2 and its ligand, delta-like 1 ligand (Dll1) …

Background B cells play a role in pregnancy due to their humoral and regulatory activities.
To our knowledge, different maturational stages (from transitional to memory) of circulating B …

B cells represent one of the cellular components of the immune system that protects the
individual from invading pathogens. In response to the invader, these cells differentiate into …

Both major subcategories of inflammatory bowel disease (IBD), ulcerative colitis and Crohn's
disease are characterized by infiltration of the gut wall by inflammatory effector cells and …

We have tracked the fate of immature human B cells at a critical stage in their development
when the mature B cell repertoire is shaped. We show that a major subset of bone marrow …

During the last two decades our understanding of human B cell differentiation has
developed considerably. Our understanding of the human B cell compartment has advanced …