B‐cell responses to HIV infection
S Moir, AS Fauci - Immunological reviews, 2017 - Wiley Online Library
The induction of neutralizing antibodies directed against the human immunodeficiency virus
(HIV) has received considerable attention in recent years, in part driven by renewed interest …
(HIV) has received considerable attention in recent years, in part driven by renewed interest …
Germinal centers: programmed for affinity maturation and antibody diversification
O Bannard, JG Cyster - Current opinion in immunology, 2017 - Elsevier
Highlights•GCs can support B cells with a range of affinities for the inducing antigen.•GC
selection involves a LZ bottleneck and differential expansion in the DZ.•Transition between …
selection involves a LZ bottleneck and differential expansion in the DZ.•Transition between …
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability
MJ Van Gils, TLGM Van Den Kerkhof, G Ozorowski… - Nature …, 2016 - nature.com
The induction by vaccination of broadly neutralizing antibodies (bNAbs) capable of
neutralizing various HIV-1 viral strains is challenging, but understanding how a subset of …
neutralizing various HIV-1 viral strains is challenging, but understanding how a subset of …
Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies
RHY Louie, KJ Kaczorowski… - Proceedings of the …, 2018 - National Acad Sciences
HIV is a highly mutable virus, and over 30 years after its discovery, a vaccine or cure is still
not available. The isolation of broadly neutralizing antibodies (bnAbs) from HIV-infected …
not available. The isolation of broadly neutralizing antibodies (bnAbs) from HIV-infected …
Antibody B cell responses in HIV-1 infection
H Mouquet - Trends in immunology, 2014 - cell.com
In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies
equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning …
equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning …
Immunologic basis for long HCDR3s in broadly neutralizing antibodies against HIV-1
L Yu, Y Guan - Frontiers in immunology, 2014 - frontiersin.org
A large number of potent broadly neutralizing antibodies (bnAbs) against HIV-1 have been
reported in recent years, raising hope for the possibility of an effective vaccine based on …
reported in recent years, raising hope for the possibility of an effective vaccine based on …
Why HIV virions have low numbers of envelope spikes: implications for vaccine development
J Schiller, B Chackerian - PLoS pathogens, 2014 - journals.plos.org
The major structural proteins of most viruses, including both naked icosahedral and
enveloped types, are present in a dense array on the virion surface. This pattern has likely …
enveloped types, are present in a dense array on the virion surface. This pattern has likely …
SARS-CoV-2 infection relaxes peripheral B cell tolerance
MJ Castleman, MM Stumpf, NR Therrien… - Journal of Experimental …, 2022 - rupress.org
Severe SARS-CoV-2 infection is associated with strong inflammation and autoantibody
production against diverse self-antigens, suggesting a system-wide defect in B cell …
production against diverse self-antigens, suggesting a system-wide defect in B cell …
SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts
RN Tasakis, G Samaras, A Jamison, M Lee, A Paulus… - PLoS …, 2021 - journals.plos.org
Since the first case of COVID-19 in December 2019 in Wuhan, China, SARS-CoV-2 has
spread worldwide and within a year and a half has caused 3.56 million deaths globally. With …
spread worldwide and within a year and a half has caused 3.56 million deaths globally. With …
Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires
The adaptive immune system is a natural diagnostic sensor and therapeutic. It recognizes
threats earlier than clinical symptoms manifest and neutralizes antigens with exquisite …
threats earlier than clinical symptoms manifest and neutralizes antigens with exquisite …