Therapeutic drug monitoring of tacrolimus-personalized therapy: second consensus report
M Brunet, T Van Gelder, A Åsberg… - Therapeutic drug …, 2019 - journals.lww.com
Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …
Calcineurin inhibitor nephrotoxicity
The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …
the field of transplantation, with excellent short-term outcome. However, the chronic …
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing
KA Birdwell, B Decker, JM Barbarino… - Clinical …, 2015 - Wiley Online Library
Tacrolimus is the mainstay immunosuppressant drug used after solid organ and
hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and …
hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and …
Tacrolimus: 20 years of use in adult kidney transplantation. What we should know about its nephrotoxicity
Y Bentata - Artificial organs, 2020 - Wiley Online Library
Abstract Tacrolimus (or FK506), a calcineurin inhibitor (CNI) introduced in field of
transplantation in the 1990s, is the cornerstone of most immunosuppressive regimens in …
transplantation in the 1990s, is the cornerstone of most immunosuppressive regimens in …
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part I
The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …
drugs used for the prevention of organ rejection following transplantation. Both agents are …
PharmGKB summary: cyclosporine and tacrolimus pathways
JM Barbarino, CE Staatz… - Pharmacogenetics …, 2013 - journals.lww.com
Tacrolimus (FK506) and cyclosporine (cyclosporin A, CsA) are cornerstone
immunosuppressive agents administered to solid organ transplant recipients to prevent and …
immunosuppressive agents administered to solid organ transplant recipients to prevent and …
Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference
P Wallemacq, VW Armstrong, M Brunet… - Therapeutic drug …, 2009 - journals.lww.com
In 2007, a consortium of European experts on tacrolimus (TAC) met to discuss the most
recent advances in the drug/dose optimization of TAC taking into account specific clinical …
recent advances in the drug/dose optimization of TAC taking into account specific clinical …
Pharmacokinetics, pharmacodynamics and pharmacogenetics of tacrolimus in kidney transplantation
M Yu, M Liu, W Zhang, Y Ming - Current drug metabolism, 2018 - ingentaconnect.com
Background: Tacrolimus (Tac, or FK506), a calcineurin inhibitor (CNI), is the first-line
immunosuppressant which consists of the footstone as immunosuppressive regimens in …
immunosuppressant which consists of the footstone as immunosuppressive regimens in …
The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation
DA Hesselink, R Bouamar, L Elens… - Clinical …, 2014 - Springer
The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …
Intra-patient variability in tacrolimus exposure: causes, consequences for clinical management
N Shuker, T van Gelder, DA Hesselink - Transplantation reviews, 2015 - Elsevier
Tacrolimus (Tac) is widely used for the prevention of rejection after solid organ
transplantation. Finding the optimal balance between effective Tac concentrations and …
transplantation. Finding the optimal balance between effective Tac concentrations and …