[HTML][HTML] Development and evolution of DNA-dependent protein kinase inhibitors toward cancer therapy

Y Matsumoto - International Journal of Molecular Sciences, 2022 - mdpi.com
DNA double-strand break (DSB) is considered the most deleterious type of DNA damage,
which is generated by ionizing radiation (IR) and a subset of anticancer drugs. DNA …

[HTML][HTML] Connection between radiation-regulating functions of natural products and miRNAs targeting radiomodulation and exosome biogenesis

JY Tang, YT Chuang, JP Shiau, CY Yen… - International journal of …, 2023 - mdpi.com
Exosomes are cell-derived membranous structures primarily involved in the delivery of the
payload to the recipient cells, and they play central roles in carcinogenesis and metastasis …

[HTML][HTML] Splice site m6A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma

X Li, J Fang, X Tao, J Xia, B Cheng, Y Wang - PeerJ, 2023 - peerj.com
Oral squamous cell carcinoma (OSCC) is the 11th most prevalent tumor worldwide. Despite
advantages of therapeutic approaches, the 5-year survival rate of patients with OSCC is less …

[HTML][HTML] A lack of effectiveness in the ATM-orchestrated DNA damage response contributes to the DNA repair defect of HPV-positive head and neck cancer cells

S Köcher, HB Zech, L Krug, F Gatzemeier… - Frontiers in …, 2022 - frontiersin.org
Patients with human papillomavirus-positive squamous cell carcinoma of the head and neck
(HPV+ HNSCC) have a favorable prognosis compared to those with HPV-negative (HPV−) …

Head and neck squamous cell carcinoma: Exploring frontiers of combinatorial approaches with tyrosine kinase inhibitors and immune checkpoint therapy

JF Scarini, L Lavareze, RA de Lima-Souza… - Critical Reviews in …, 2022 - Elsevier
Squamous cell carcinomas (SCC) are the most common malignant tumors that arise in the
head and neck. Despite advances in the management of affected patients, the mortality …

[HTML][HTML] Comprehensive analysis of mitophagy in HPV-related head and neck squamous cell carcinoma

L Yanan, L Hui, C Zhuo, D Longqing, S Ran - Scientific Reports, 2023 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is a common tumour type in
otorhinolaryngology, and its occurrence is related to long-term exposure to tobacco and …

[HTML][HTML] Micro-RNAs, the cornerstones of the future of radiobiology in head and neck cancers?

CC Mireștean, RI Iancu, DPT Iancu - Current Oncology, 2022 - mdpi.com
Even though it is only the 6th most common malignancy at the modal level, head and neck
cancers are distinguished by a considerable treatment failure rate, especially by …

[HTML][HTML] Expression and molecular regulation of non-coding RNAs in HPV-positive head and neck squamous cell carcinoma

D Guo, M Yang, S Li, W Zhu, M Chen, J Pan… - Frontiers in …, 2023 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy
worldwide. Accumulating evidence suggests that persistent HPV infection is closely related …

Are we ready for deintensification in human papillomavirus-positive oropharyngeal carcinomas?

SH Huang, E Hahn, R Salunkhe… - Current Opinion in …, 2023 - journals.lww.com
Substantial effort has been expended to explore deintensification options for selected HPV+
OPC patients aiming to avoid unnecessary toxicity. Strategies have included replacing …