Moving the pathway goalposts: COPD as an immune-mediated inflammatory disease

SP Cass, AP Cope, DV Nicolau… - The Lancet …, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) encompasses a spectrum of lung disorders
that cause lung function decline. The degree by which lung function has decreased is used …

Genetic insights into the gut-lung axis: Mendelian randomization analysis on gut microbiota, lung function, and COPD

ZX Cheng, JL Hua, ZJ Jie, XJ Li… - International Journal of …, 2024 - Taylor & Francis
Background Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with a
complex etiology involving genetic and environmental factors. The dysbiosis of gut …

Lung imaging in COPD part 1: clinical usefulness

S Raoof, M Shah, B Make, H Allaqaband, R Bowler… - Chest, 2023 - Elsevier
COPD is a condition characterized by chronic airflow obstruction resulting from chronic
bronchitis, emphysema, or both. The clinical picture is usually progressive with respiratory …

Wnt3a‐Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury

L Gao, Y Sun, X Zhang, D Ma, A Xie, E Wang… - Advanced …, 2023 - Wiley Online Library
Compromised regeneration resulting from the deactivation of Wnt/β‐catenin signaling
contributes to the progression of chronic obstructive pulmonary disease (COPD) with limited …

Comparing the performance of two screening questionnaires for chronic obstructive pulmonary disease in the Chinese general population

M Liu, D Yin, Y Wang, W Wang, T Fu… - … journal of chronic …, 2023 - Taylor & Francis
Purpose Screening questionnaires can help identify individuals at a high risk of COPD. This
study aimed to compare the performance of the COPD population screener (COPD-PS) and …

Detection of Chest X-ray Abnormalities Using CNN Based on Hyperparameter Optimization

S Saifullah, B Yuwono, HC Rustamaji, B Saputra… - Engineering …, 2023 - mdpi.com
The chest X-ray (CXR) is a commonly used diagnostic imaging test that requires significant
expertise and careful observation due to the complex nature of the pathology and fine …

Nonpharmacological interventions in COPD

W Janssens, GM Verleden - European Respiratory Review, 2023 - Eur Respiratory Soc
COPD is recognised as one of the major health challenges for the coming decades. This is
primarily driven by a growing burden of the disease due to persistent exposure to tobacco …

Genetic and Epigenetic Associations with Pre–Chronic Obstructive Pulmonary Disease Lung Function Trajectories

DJ Martino, DS Bui, S Li, S Idrose, J Perret… - American Journal of …, 2023 - atsjournals.org
Rationale: Understanding the pathobiology of life-course lung function trajectories that
progress to COPD, especially with a rapidly declining phenotype, can inform preventive …

Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning

D Zöller, C Haverkamp, A Makoudjou, G Sofack… - Respiratory …, 2024 - Springer
Background Chronic obstructive pulmonary disease (COPD) is an inflammatory
multisystemic disease caused by environmental exposures and/or genetic factors. Inherited …

COPD Risk Factor Profiles in General Population and Referred Patients: Potential Etiotypes

JH Lee, S Kim, YJ Kim, SW Lee, JS Lee… - International Journal of …, 2023 - Taylor & Francis
Purpose To identify the risk factors for chronic obstructive pulmonary disease (COPD) in
view of potential etiotypes in a general population and referred COPD patients. Patients and …