Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Abstract Background Urolithin A (URA) is an intestinal microbiota metabolic product from
ellagitannin-containing foods with multiple biological activities. However, its role in …

Group 3 innate lymphoid cells (ILC3s) play critical roles in innate immunity and gut
homeostasis. However, how ILC3 homeostasis is regulated remains elusive. Here, we …

Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease.
The expression of Nur77 increases upon stimulation of immune cells and is differentially …

Recent evidence has shown that neuroinflammation plays a key role in the pathogenesis of
Parkinson's disease (PD). However, different components of the brain's immune system may …

Increasing data suggest a crucial role of circadian rhythm in regulating metabolic and
neurological diseases, and Bmal1 is regarded as a key regulator of circadian transcription …

The nuclear receptor Nur77 is expressed in a multitude of tissues, regulating cell
differentiation and homeostasis. Dysregulation of Nur77 signaling is associated with cancer …

Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine
have been used for thousands of years. Carnosol as a bioactive diterpene compound …

Low grade, chronic inflammation is a critical risk factor for immunologic dysfunction including
autoimmune diseases. However, the multiplicity of complex mechanisms and lack of …