Idiopathic pulmonary fibrosis: current status, recent progress, and emerging targets

YM Liu, K Nepali, JP Liou - Journal of medicinal chemistry, 2017 - ACS Publications
Idiopathic pulmonary fibrosis (IPF), a chronic and progressive fibrosing interstitial
pneumonia, is a fatal lung disease with a median survival time of 3–5 years. Problems in …

[HTML][HTML] The inflammasome NLR family pyrin domain-containing protein 3 (NLRP3) as a novel therapeutic target for idiopathic pulmonary fibrosis

RMLC Biancatelli, PA Solopov, JD Catravas - The American Journal of …, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a dramatic disease without cure. The US Food and
Drug Administration–approved drugs, pirfenidone and nintedanib, only slow disease …

Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice

EA Shamskhou, MJ Kratochvil, ME Orcholski, N Nagy… - Biomaterials, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a life-threatening progressive lung disorder with limited
therapeutic options. While interleukin-10 (IL-10) is a potent anti-inflammatory and anti …

[HTML][HTML] Current approaches to the management of idiopathic pulmonary fibrosis

G Raghu, L Richeldi - Respiratory medicine, 2017 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease
associated with dyspnoea, cough and impaired quality of life. Currently, the aims of patient …

Lung function and cardiovascular disease: a two-sample Mendelian randomisation study

DH Higbee, R Granell, E Sanderson… - European …, 2021 - Eur Respiratory Soc
Background Observational studies suggest an association between reduced lung function
and risk of coronary artery disease and ischaemic stroke, independent of shared …

ROS-responsive microneedles loaded with integrin avβ6-blocking antibodies for the treatment of pulmonary fibrosis

H Ding, Y Cui, J Yang, Y Li, H Zhang, S Ju… - Journal of Controlled …, 2023 - Elsevier
Pulmonary fibrosis (PF) is a fibrotic interstitial pneumonia with poor prognosis and limited
treatment methods. Inhibition of integrin α V β 6 expression could prevent pulmonary …

Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis

JW Barnes, D Duncan, S Helton… - … of Physiology-Lung …, 2019 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia
that mainly affects the elderly. Several reports have demonstrated that aging is involved in …

Safety and efficacy of nintedanib in idiopathic pulmonary fibrosis: a real-life observational study in Greece

A Tzouvelekis, T Karampitsakos, M Kontou… - Pulmonary …, 2018 - Elsevier
Background Nintedanib represents an antifibrotic compound able to slow down disease
progression of patients with idiopathic pulmonary fibrosis (IPF). Objective To investigate the …

Targeting sphingosine-1-phosphate signaling in lung diseases

DL Ebenezer, P Fu, V Natarajan - Pharmacology & therapeutics, 2016 - Elsevier
Abstract Sphingosine-1-phosphate (S1P), a simple, bioactive sphingolipid metabolite, plays
a key role, both intracellularly and extracellularly, in various cellular processes such as …

Evaluation of glutathione S-transferase inhibition effects on idiopathic pulmonary fibrosis therapy with a near-infrared fluorescent probe in cell and mice models

N He, S Bai, Y Huang, Y Xing, L Chen, F Yu… - Analytical …, 2019 - ACS Publications
Idiopathic pulmonary fibrosis (IPF) is a lung-limited and progressive fibrotic disease. The
early diagnosis and therapies of IPF are still full of clinical challenges. Glutathione S …