Glucagon has been defined as an 'insulin counteracting hormone', which raises blood
glucose levels. Recent progress in basic research has shown that glucagon is closely …

Diabetes is caused by insufficient insulin secretion due to β-cell dysfunction and/or β-cell
loss. Therefore, the restoration of functional β-cells by the induction of β-cell differentiation …

As diabetes results from the absolute or relative deficiency of insulin secretion from
pancreatic β cells, possible methods to efficiently generate surrogate β cells have attracted a …

Aims/hypothesis Beta cells within the pancreatic islet represent a heterogenous population
wherein individual sub-groups of cells make distinct contributions to the overall control of …

Aims/hypothesis Glucagon-expressing pancreatic alpha cells have attracted much attention
for their plasticity to transdifferentiate into insulin-producing beta cells; however, it remains …

Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world;
it has numerous clinical, immunological, and genetic differences from type 1 diabetes …

This article describes a stem cell line derived by reprogramming of native human islet cells
that consistently generates pure populations of endocrine pancreatic clusters following a …

A stem cell line, derived by reprogramming native human islet cells, consistently generates
pure populations of endocrine pancreatic clusters following differentiation cues. Two …

Нарушения углеводного обмена представляют собой одну из важнейших
медикосоциальных проблем. Отклонения в содержании сахара в крови как в сторону …

Results Ectopic expression of Pdx1 induced STAT3 activation in α cells. STAT3 has been
shown to be activated in pancreatic acinar cells that ectopically express Pdx1 6, 15. To …