Newly discovered knowledge pertaining to glucagon and its clinical applications
D Kawamori, S Sasaki - Journal of Diabetes Investigation, 2023 - Wiley Online Library
Glucagon has been defined as an 'insulin counteracting hormone', which raises blood
glucose levels. Recent progress in basic research has shown that glucagon is closely …
glucose levels. Recent progress in basic research has shown that glucagon is closely …
[HTML][HTML] Heterogeneity of islet cells during embryogenesis and differentiation
S Sasaki, T Miyatsuka - Diabetes & Metabolism Journal, 2023 - synapse.koreamed.org
Diabetes is caused by insufficient insulin secretion due to β-cell dysfunction and/or β-cell
loss. Therefore, the restoration of functional β-cells by the induction of β-cell differentiation …
loss. Therefore, the restoration of functional β-cells by the induction of β-cell differentiation …
[HTML][HTML] STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1
Y Wakabayashi, T Miyatsuka, M Miura, M Himuro… - Scientific Reports, 2022 - nature.com
As diabetes results from the absolute or relative deficiency of insulin secretion from
pancreatic β cells, possible methods to efficiently generate surrogate β cells have attracted a …
pancreatic β cells, possible methods to efficiently generate surrogate β cells have attracted a …
[HTML][HTML] Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
V Yu, F Yong, A Marta, S Khadayate, A Osakwe… - Diabetologia, 2024 - Springer
Aims/hypothesis Beta cells within the pancreatic islet represent a heterogenous population
wherein individual sub-groups of cells make distinct contributions to the overall control of …
wherein individual sub-groups of cells make distinct contributions to the overall control of …
Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
M Himuro, Y Wakabayashi, T Taguchi, T Katahira… - Diabetologia, 2024 - Springer
Aims/hypothesis Glucagon-expressing pancreatic alpha cells have attracted much attention
for their plasticity to transdifferentiate into insulin-producing beta cells; however, it remains …
for their plasticity to transdifferentiate into insulin-producing beta cells; however, it remains …
[HTML][HTML] Type 2 diabetes mellitus: pathogenic features and experimental models in rodents
MV Karimova, AV Vasiliev… - Acta Naturae …, 2022 - cyberleninka.ru
Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world;
it has numerous clinical, immunological, and genetic differences from type 1 diabetes …
it has numerous clinical, immunological, and genetic differences from type 1 diabetes …
Novel MAFA+, ISL1+, NKX6-1-stem cell derived pancreatic cell clusters secrete insulin and control blood glucose in rodent models of diabetes
J Ratiu, S Southard, W Rust - bioRxiv, 2023 - biorxiv.org
This article describes a stem cell line derived by reprogramming of native human islet cells
that consistently generates pure populations of endocrine pancreatic clusters following a …
that consistently generates pure populations of endocrine pancreatic clusters following a …
The transcription factors ISL-1 and MAFA, but not NKX6-1 Characterize a Stem-cell Derived Population of Endocrine Pancreatic Cells Capable of Controlling blood …
J Ratiu, SM Southard, WL Rust - Medical Research Archives, 2023 - esmed.org
A stem cell line, derived by reprogramming native human islet cells, consistently generates
pure populations of endocrine pancreatic clusters following differentiation cues. Two …
pure populations of endocrine pancreatic clusters following differentiation cues. Two …
[PDF][PDF] ВЛИЯНИЕ МАКРОФАГОВ НА СОСТОЯНИЕ ИНСУЛИН-СИНТЕЗИРУЮЩИХ КЛЕТОК РАЗЛИЧНОЙ ЛОКАЛИЗАЦИИ В ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЕ
ТС БУЛАВИНЦЕВА - iip.uran.ru
Нарушения углеводного обмена представляют собой одну из важнейших
медикосоциальных проблем. Отклонения в содержании сахара в крови как в сторону …
медикосоциальных проблем. Отклонения в содержании сахара в крови как в сторону …
STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1
若林侑香, ワカバヤシユカ - 2022 - jair.repo.nii.ac.jp
Results Ectopic expression of Pdx1 induced STAT3 activation in α cells. STAT3 has been
shown to be activated in pancreatic acinar cells that ectopically express Pdx1 6, 15. To …
shown to be activated in pancreatic acinar cells that ectopically express Pdx1 6, 15. To …