Stem cell‐based therapy has been indicated to be beneficial for intervertebral disc
regeneration. However, the underlying mechanisms have not been fully identified. The …

The cartilaginous endplate (CEP) is a thin layer of hyaline cartilage, and plays an important
role in the diffusion of nutrients into the intervertebral discs. Its damage may seriously affect …

Because low back pain is frequently a result of intervertebral disc degeneration (IVDD),
strategies to regenerate or repair the IVD are currently being investigated. Often, ex vivo disc …

Background: Degenerative disk disease (DDD) remains the leading incentive of severe
lumbago. DDD is mainly caused by degeneration of cartilage endplate (CEP). Cartilage …

Objective Cartilaginous endplate (CEP) degeneration is the main early manifestations of
intervertebral disc degeneration (IVDD), and is closely related to the oxidative stress. Nrf2 …

Purpose There is considerable controversy on the role of genetics, mechanical and
environmental factors, and, recently, on subclinical infection in triggering inflammaging …

Regenerative injection therapy is an evolving interventional treatment that provides
alternative solutions for different musculoskeletal conditions. Recent advances in research …

Background To clarify if a2-macroglobulin (α2M) has an antioxidative effect during the
progression of the intervertebral disc degeneration (IVDD). Methods The content of α2M and …

Degenerative disk disease is a pathologic state associated with axial skeletal pain,
radiculopathy, and myelopathy, and will inevitably increase in prevalence in parallel with an …

Background Propionibacterium acnes (P. acnes) is a novel pathogenic factor that
contributes to cartilaginous endplate (CEP) degeneration. However, the underlying …