Giulio Tononi's integrated information theory (IIT) proposes explaining consciousness by
directly identifying it with integrated information. We examine the construct validity of IIT's …

Abstract Spinocerebellar ataxia type 1 (SCA1) is one of nine polyglutamine (polyQ) diseases
and is characterized as an adult late-onset, progressive, dominantly inherited genetic …

Feedback pathways are a common circuit motif in vertebrate brains. Reciprocal
interconnectivity is seen between the cerebral cortex and thalamus as well as between …

Essential Tremor (ET) is a prevalent neurological disease characterized by an 8–10 Hz
action tremor. Molecular mechanisms of ET remain poorly understood. Clinical data suggest …

Despite previous functional MRI studies on alterations within the cerebello-thalamo-cortical
circuit in patients with essential tremor (ET), the specific role of disconnection of the dentate …

Anatomical connections link the cerebellar cortex with multiple sensory, motor, association,
and paralimbic cerebral areas. The majority of fibers that exit cerebellar cortex synapse in …

Amyotrophic lateral sclerosis (ALS) is characterized primarily by motor neuron but also
frontotemporal lobar degeneration. Although the cerebellum is involved in both motor and …

Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor
learning are gaining interest in systems neuroscience and clinical research. Current …

Anatomical studies in animals and imaging studies in humans show that cerebral
sensorimotor areas map onto corresponding cerebellar sensorimotor areas and that …

The dentato-rubro-thalamo-cortical tract (DRTC) is the main outflow pathway of the
cerebellum, contributing to a finely balanced corticocerebellar loop involved in cognitive and …