As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

Background Pyroptosis is a new programmed cell death discovered in recent years.
Pyroptosis plays an important role in various diseases. Nevertheless, there are few …

The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1
and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from …

Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …