[HTML][HTML] Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human …
WJ Pandori, TS Lima, S Mallya, TH Kao, L Gov… - PLoS …, 2019 - journals.plos.org
IL-1β is a potent pro-inflammatory cytokine that promotes immunity and host defense, and its
dysregulation is associated with immune pathology. Toxoplasma gondii infection of myeloid …
dysregulation is associated with immune pathology. Toxoplasma gondii infection of myeloid …
[HTML][HTML] Cellular models and assays to study NLRP3 inflammasome biology
The NLRP3 inflammasome is a multi-protein complex that initiates innate immunity
responses when exposed to a wide range of stimuli, including pathogen-associated …
responses when exposed to a wide range of stimuli, including pathogen-associated …
[HTML][HTML] Mesenchymal stem cells protect against TBI-induced pyroptosis in vivo and in vitro through TSG-6
Z Feng, S Hua, W Li, J Han, F Li, H Chen… - Cell Communication and …, 2022 - Springer
Background Pyroptosis, especially microglial pyroptosis, may play an important role in
central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of …
central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of …
[HTML][HTML] Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis
X Wang, X Wei, Y Lu, Q Wang, R Fu, Y Wang… - PLoS …, 2023 - journals.plos.org
Members of the gasdermin (GSDM) family are pore-forming effectors that cause membrane
permeabilization and pyroptosis, a lytic proinflammatory type of cell death. To reveal the …
permeabilization and pyroptosis, a lytic proinflammatory type of cell death. To reveal the …
Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure
W Xu, Q Zhang, C Ding, H Sun, Y Che… - Acta Pharmacologica …, 2021 - nature.com
Programmed cell death (PCD), including apoptosis, apoptotic necrosis, and pyroptosis, is
involved in various organ dysfunction syndromes. Recent studies have revealed that a …
involved in various organ dysfunction syndromes. Recent studies have revealed that a …
Structural insight of gasdermin family driving pyroptotic cell death
J Ruan - Structural Immunology, 2019 - Springer
Gasdermin is a recently identified family of pore-forming proteins consisting of Gasdermin A
(GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD) …
(GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD) …
Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease
BE Bolívar, TP Vogel, L Bouchier‐Hayes - The FEBS journal, 2019 - Wiley Online Library
Members of the mammalian inflammatory caspase family, including caspase‐1, caspase‐4,
caspase‐5, caspase‐11, and caspase‐12, are key regulators of the innate immune …
caspase‐5, caspase‐11, and caspase‐12, are key regulators of the innate immune …
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis
J Wang, L Wang, X Zhang, Y Xu, L Chen… - International …, 2021 - Elsevier
Abstract Objectives Cathepsin B (CTSB), nod-like receptor family pyrin domain-containing 3
(NLRP3), and caspase-1 play an important role in the development of Acute Pancreatitis …
(NLRP3), and caspase-1 play an important role in the development of Acute Pancreatitis …
[HTML][HTML] Identification of key pyroptosis-related genes and distinct pyroptosis-related clusters in periodontitis
Aim This study aims to identify pyroptosis-related genes (PRGs), their functional immune
characteristics, and distinct pyroptosis-related clusters in periodontitis. Methods Differentially …
characteristics, and distinct pyroptosis-related clusters in periodontitis. Methods Differentially …
Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice
H Che, H Li, Y Li, YQ Wang, ZY Yang… - The FASEB …, 2020 - Wiley Online Library
Diabetes mellitus (DM) patients are at a higher risk of developing brain injury characterized
by neuronal death. Melatonin, a hormone produced by the pineal gland, exerts …
by neuronal death. Melatonin, a hormone produced by the pineal gland, exerts …