High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

D Zhou, RA Hlady, MJ Schafer, TA White, C Liu… - Epigenetics, 2017 - Taylor & Francis
High-fat diet consumption and sedentary lifestyle elevates risk for obesity, non-alcoholic fatty
liver disease, and cancer. Exercise training conveys health benefits in populations with or …

Biomaterial design inspired by regenerative research organisms

S Sapru, MN Dill, CS Simmons - ACS biomaterials science & …, 2022 - ACS Publications
The efficacy of implanted biomaterials is largely dependent on the response of the host's
immune and stromal cells. Severe foreign body response (FBR) can impede the integration …

Prenatal transportation stress alters genome-wide DNA methylation in suckling Brahman bull calves,

BP Littlejohn, DM Price, DA Neuendorff… - Journal of Animal …, 2018 - academic.oup.com
The objective of this experiment was to identify genome-wide differential methylation of DNA
in young prenatally stressed (PNS) bull calves. Mature Brahman cows (n= 48) were …

[HTML][HTML] DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions

MJ Barter, C Bui, K Cheung, J Falk, R Gómez… - Scientific Reports, 2020 - nature.com
Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic
mechanisms including DNA methylation. Methylation changes may also play a key role in …

[HTML][HTML] Targeted DNA demethylation: vectors, effectors and perspectives

N Yano, AV Fedulov - Biomedicines, 2023 - mdpi.com
Aberrant DNA hypermethylation at regulatory cis-elements of particular genes is seen in a
plethora of pathological conditions including cardiovascular, neurological, immunological …

Advances in measuring DNA methylation

R Sun, P Zhu - Blood Science, 2022 - mednexus.org
DNA methylation is one of the most important components of epigenetics, which plays
essential roles in maintaining genome stability and regulating gene expression. In recent …

[HTML][HTML] DNA methylation alterations in fractionally irradiated rats and breast cancer patients receiving radiotherapy

M Sallam, M Mysara, MA Benotmane… - International journal of …, 2022 - mdpi.com
Radiation-Induced CardioVascular Disease (RICVD) is an important concern in thoracic
radiotherapy with complex underlying pathophysiology. Recently, we proposed DNA …

[HTML][HTML] Epigenetic features of human perinatal stem cells redefine their stemness potential

G Gaggi, A Di Credico, P Izzicupo, I Antonucci… - Cells, 2020 - mdpi.com
Human perinatal stem cells (SCs) can be isolated from fetal annexes without ethical or
safety limitations. They are generally considered multipotent; nevertheless, their biological …

Magnetic resonance imaging and deoxyribonucleic acid methylation–based radiogenomic models for survival risk stratification of glioblastoma

W Zhang, Z Yan, J Peng, S Zhao, L Ran, H Yin… - Medical & Biological …, 2024 - Springer
Glioblastoma multiforme (GBM) is one of the deadliest tumours. This study aimed to
construct radiogenomic prognostic models of glioblastoma overall survival (OS) based on …

Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation

AS Duddu, SS Majumdar, S Sahoo… - Molecular Biology of …, 2022 - Am Soc Cell Biol
Naïve helper (CD4+) T-cells can differentiate into distinct functional subsets including Th1,
Th2, and Th17 phenotypes. Each of these phenotypes has a “master regulator”—T-bet …