Purpose Human pluripotent stem cell (hPSC)-derived dopaminergic neuron progenitor cells
(DAPCs) are a potential therapy for Parkinson's disease (PD). However, their intracranial …

DNA methylation is an epigenetic mark implicated in crucial biological processes. Most of
the knowledge about DNA methylation is based on bulk experiments, in which DNA …

Change in gene expression is inevitable in cancer development. With more studies
demonstrating the contributions of cancer stem cells (CSCs) in colorectal cancer (CRC) …

The first differentiation event in mammalian embryos is the formation of the trophectoderm,
which is the progenitor of the outer epithelial components of the placenta, and which …

As development varies greatly across the tree of life, it may seem difficult to suggest a model
that proposes a single mechanism for understanding collective cell behaviors and the …

DNA replication in high eukaryotes requires the faithful transmission of both the sequence
and its methylation status. DNA methyltransferases are not consistently reliable enzymes for …

Although DNA methylation epigenetically regulates development, data on global DNA
methylation during the development of limb buds (LBs) are scarce. We aimed to investigate …

The field of epigenetics, which is the study of factors regulating gene transcription, is
expanding rapidly. Yet one area that has received little attention is the influence of …

Cdkn1c, a member of the Cip/Kip cyclin-dependent kinase inhibitor family, is critically
involved in regulating cell cycle and cellular differentiation during development in mammals …

Background: Currently, there are no effective differentiation-inducing agents for gliomas.
Drug repositioning is a time-saving, low-risk, and low-cost drug development strategy. In this …