Background Major depressive disorder is one of the most common, burdensome, and costly
psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological …

Background: Mounting evidence demonstrates enhanced systemic levels of inflammatory
mediators in depression, indicating that inflammation may play a role in the etiology and …

Thiazolidinediones have shown antidepressant effect in animal studies, as well as in some
uncontrolled studies evaluating human subjects with concurrent major depressive disorder …

Studies have found that up to two-thirds of patients with major depressive disorder (MDD) do
not fully respond to the first antidepressant. While switching antidepressants is a common …

Accumulating evidence suggests that early improvement after two‐week antidepressant
treatment is predictive of later outcomes of patients with major depressive disorder (MDD); …

There is still considerable controversy about the onset and time course of improvement with
antidepressants in the treatment of major depressive disorder. Previous studies suggested a …

Background The absence of biomarkers for predicting treatment response in adolescent
mood disorder calls for further research. The vermis, a component of the cerebellum, is …

Background Initial improvement in the first weeks of antidepressant (AD) treatment is a
useful early predictor of complete AD response. We performed a meta-analysis of AD …

Bakgroud The hippocampus is involved in the pathophysiology of major depressive disorder
(MDD), and its structure and function have been reported to be related to the antidepressant …

BackgroundThe present study investigated alteration of brain resting-state activity induced
by antidepressant treatment and attempted to investigate whether treatment efficacy can be …