Neurogenic hypertension, the blood–brain barrier, and the potential role of targeted nanotherapeutics

RNL Lamptey, C Sun, B Layek, J Singh - International Journal of …, 2023 - mdpi.com
Hypertension is a major health concern globally. Elevated blood pressure, initiated and
maintained by the brain, is defined as neurogenic hypertension (NH), which accounts for …

The paraventricular nucleus of the hypothalamus–the concertmaster of autonomic control. Focus on blood pressure regulation

E Grzęda, K Ziarniak, JH Sliwowska - Acta neurobiologiae experimentalis, 2023 - ane.pl
The autonomic nervous system regulates internal organs and peripheral circulation, which
enables the maintenance of homeostasis in vertebrate species. One of the brain regions …

Time in target range of systolic blood pressure and cognitive outcomes in patients with hypertension

X Huang, S Deng, W Xie… - Journal of the American …, 2024 - Wiley Online Library
Background Blood pressure (BP) is a dynamic measure that fluctuates over time. However,
conventional BP control indicators may not adequately reflect the variability of BP during a …

The sympathetic nervous system in hypertensive heart failure with preserved LVEF

F Triposkiadis, A Briasoulis, P Sarafidis… - Journal of Clinical …, 2023 - mdpi.com
The neurohormonal model of heart failure (HF) pathogenesis states that a reduction in
cardiac output caused by cardiac injury results in sympathetic nervous system (SNS) …

Circuit-specific control of blood pressure by PNMT-expressing nucleus tractus solitarii neurons

S Jun, X Ou, L Shi, H Yu, T Deng, J Chen, X Nie… - Neuroscience …, 2023 - Springer
The nucleus tractus solitarii (NTS) is one of the morphologically and functionally defined
centers that engage in the autonomic regulation of cardiovascular activity. Phenotypically …

[HTML][HTML] The role of arginine-vasopressin in stroke and the potential use of arginine-vasopressin type 1 receptor antagonists in stroke therapy: A narrative review

K Chojnowski, M Opiełka, J Gozdalski… - International Journal of …, 2023 - mdpi.com
Stroke is a life-threatening condition in which accurate diagnoses and timely treatment are
critical for successful neurological recovery. The current acute treatment strategies …

Gestational intermittent hypoxia increases FosB‐immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats

D Ambrozio‐Marques, M Gagnon… - Experimental …, 2023 - Wiley Online Library
Sleep‐disordered breathing is a respiratory disorder commonly experienced by pregnant
women. The recurrent hypoxaemic events associated with sleep‐disordered breathing have …

Increased GABAergic projections in the paraventricular nucleus regulate colonic hypersensitivity via oxytocin in a rat model of irritable bowel syndrome

J Li, H Liu, F Guo, R Guo, H Zhang, X He, X Ming… - …, 2023 - journals.lww.com
Irritable bowel syndrome (IBS) is characterized by gastrointestinal dysmotility and visceral
hyperalgesia, and the impaired brain–gut axis is accepted as a crucial cause for the onset of …

Modulating activity of PVN neurons prevents atrial fibrillation induced circulation dysfunction by electroacupuncture at BL15

J Wang, Q Zhang, L Yao, T He, X Chen, Y Su, S Sun… - Chinese Medicine, 2023 - Springer
Background Circulation dysfunction is a major contributing factor to thrombosis in patients
with atrial fibrillation (AF) for which effective interventions are lacking. Growing evidence …

Vasopressin and cardiovascular autonomic adjustment in chronic hypertensive pregnancy

M Jovanović, B Stevanović, V Pajović, T Tasić… - Hypertension …, 2024 - nature.com
Chronic hypertensive pregnancy (CHP) is a growing health issue with unknown etiology.
Vasopressin (VP), a nonapeptide synthesized in paraventricular (PVN) and supraoptic …