Microbiome data, metadata and analytical workflows have become 'big'in terms of volume
and complexity. Although the infrastructure and technologies to share data have been …

As the second year of the COVID-19 pandemic begins, it remains clear that a massive
increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to …

Background Long sequencing reads are information-rich: aiding de novo assembly and
reference mapping, and consequently have great potential for the study of microbial …

Background One of the main challenges in metagenomics is the identification of
microorganisms in clinical and environmental samples. While an extensive and …

Modern metagenomic environmental DNA studies are almost completely reliant on next-
generation sequencing, making evaluations of these methods critical. We compare two next …

The importance of diversity and cellular specialization is clear for many reasons, from
population-level diversification, to improved resiliency to unforeseen stresses, to unique …

Background and objectives: In recent years, many different culture-independent molecular
techniques have been developed with the aim of investigating the not yet cultivated part of …

Highlights•Growing evidence indicates that the microbiome plays an important role in health
and disease.•Reliable and meaningful scientific conclusions from microbiome studies rely …

Advancements in next-generation sequencing technology have dramatically reduced the
cost and increased the ease of microbial whole genome sequencing. This approach is …

The complexity of microbial communities, combined with technical biases in next-generation
sequencing, pose a challenge to metagenomic analysis. Here, we develop a set of internal …