A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Short-chain fatty acids (SCFAs) are the main metabolites produced by the bacterial
fermentation of dietary fiber, and they play a critical role in the maintenance of intestinal …

Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of
statins, niacin was commonly used to counter dyslipidemia. Recent evidence has posited …

Globally, breast cancer is the most frequent type of cancer in women, and most breast
cancer-associated deaths are due to metastasis and recurrence of the disease. Dietary …

Obesity has a noteworthy role in breast tumor initiation and progression. Among the
mechanisms proposed, the most validated is the development of chronic low-grade …

Cancer cells display metabolic alterations to meet the bioenergetic demands for their high
proliferation rates. Succinate is a central metabolite of the tricarboxylic acid (TCA) cycle, but …

Short-chain fatty acids (SCFAs) play a pivotal role in regulating the proliferation and
development of bovine rumen epithelial cells (BRECs). G protein-coupled receptor 41 …

G protein-coupled receptors (GPCRs) have originally been described as a family of
receptors activated by hormones, neurotransmitters, and other mediators. However, in …

Trace amine-associated receptors (TAAR1-TAAR9) are a family of G-protein-coupled
monoaminergic receptors which might have great pharmacological potential. It has now …

Simple Summary Renal cell carcinoma (RCC) is one of the most life-threatening urological
neoplasms. The tumor microenvironment comprising immune cell infiltration is a key factor …