Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …

Heavy metal pollution not only poses a serious threat to both animal growth and public
health, but also to aquatic life. Mitochondria are the first target sites for a variety of heavy …

Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …

One of the major mechanisms of drug-induced liver injury includes mitochondrial
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …

Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we
show that Mitochondrial Fission Process 1 (MTFP1) is an inner mitochondrial membrane …

Mitochondrial mass imbalance is one of the key causes of cardiovascular dysfunction after
hypoxia. The activation of dynamin-related protein 1 (Drp1), as well as its mitochondrial …

Simple Summary The regulation of hypoxia has recently emerged as having a central impact
in mitochondrial function and dysfunction in various diseases, including the major disorders …

Mitochondrial dysfunction is one of the fundamental causes of ischemia reperfusion (I/R)
damage. I/R refers to the paradoxical progression of cellular dysfunction and death that …

Human diseases are characterized by the perpetuation of an inflammatory condition in
which the levels of Reactive Oxygen Species (ROS) are quite high. Excessive ROS …