Histone modifications and RNA splicing, two seemingly unrelated gene regulatory
processes, greatly increase proteome diversity and profoundly influence normal as well as …

Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its
metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the …

Although the viral genome is often quite small, it encodes a broad series of proteins. The
virus takes advantage of the host-RNA-processing machinery to provide the alternative …

Most human pre-mRNA transcripts are alternatively spliced, but the significance and fine-
tuning of alternative splicing in different biological processes is only starting to be …

It has been assumed that premessenger ribonucleic acids (RNAs; pre-mRNAs) are spliced
cotranscriptionally in the process of gene expression. However, in this paper, we report that …

Both well‐known and emerging viruses increasingly affect humans and cause disease,
sometimes with devastating impact on society. The viruses present in the biosphere are the …

Influenza virus is an RNA virus encapsulated in a lipid bilayer derived from the host cell
plasma membrane. Previous studies showed that influenza virus infection depends on …

Annual influenza outbreaks are associated with significant morbidity and mortality worldwide
despite the availability of seasonal vaccines. Influenza pathogenesis depends on the …

Oncolytic virotherapy has recently emerged as a promising strategy for inducing tumor-
specific cell death. Adenoviruses are widely and frequently used in oncolytic virotherapy …

Influenza virus is an enveloped virus wrapped in a lipid bilayer derived from the host cell
plasma membrane. Infection by influenza virus is dependent on these host cell lipids, which …