The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …

Poly (ADP-ribose)(PAR) Polymerase 1 (PARP-1), also known as ADP-ribosyl transferase
with diphtheria toxin homology 1 (ARTD-1), is a critical player in DNA damage repair, during …

Efficient humoral responses rely on DNA damage, mutagenesis and error-prone DNA repair.
Diversification of B cell receptors through somatic hypermutation and class-switch …

Germinal centers (GCs) play a central role in generating an effective immune response
against infectious pathogens, and failures in their regulating mechanisms can lead to the …

Simple Summary Cancer is associated with metabolic changes related to increased cell
proliferation and growth. These cancer-related metabolic features are largely dictated by …

Simple Summary DNA repair pathways play a crucial role in maintaining the stability of a
cell's genetic material. When these pathways are defective, it can lead to genomic instability …

Dichloropropane (1, 2-DCP), a synthetic organic solvent, has been implicated in causality of
cholangiocarcinoma (bile duct cancer). 1, 2-DCP-induced occupational cholangiocarcinoma …

APE2 is a rising vital player in the maintenance of genome and epigenome integrity. In the
past several years, a series of studies have shown the critical roles and functions of APE2 …

Oxidized bases in the genome has been implicated in various human pathologies, including
cancer, aging and neurological diseases. Their repair is initiated with excision by DNA …

Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both
through pathogenesis and during disease progression. Despite recent advances in therapy …