Advances in ovarian cancer treatment beyond PARP inhibitors

F Aliyuda, M Moschetta, A Ghose… - Current Cancer Drug …, 2023 - ingentaconnect.com
Ovarian cancer has become the largest cause of gynaecological cancer-related mortality. It
is typically diagnosed at a late stage and has no effective screening strategy. Ovarian cancer …

Hereditary ovarian cancer: towards a cost-effective prevention strategy

A Ghose, A Bolina, I Mahajan, SA Raza… - International Journal of …, 2022 - mdpi.com
Ovarian cancer (OC) is the most lethal gynaecological malignancy. The search for a widely
affordable and accessible screening strategy to reduce mortality from OC is still ongoing …

Clinical challenges in the management of malignant ovarian germ cell tumours

I Saani, N Raj, R Sood, S Ansari… - International journal of …, 2023 - mdpi.com
Nonepithelial ovarian cancers (NEOC) are a group of rare malignancies, including germ cell
tumours (GCT) and sex cord-stromal tumours (SCST), along with small-cell carcinomas and …

Clinical application of PARP inhibitors in ovarian cancer: from molecular mechanisms to the current status

Y Wu, S Xu, S Cheng, J Yang, Y Wang - Journal of Ovarian Research, 2023 - Springer
As a kind of gynecological tumor, ovarian cancer is not as common as cervical cancer and
breast cancer, but its malignant degree is higher. Despite the increasingly mature treatment …

Novel cuproptosis-related long non-coding RNA signature to predict prognosis in prostate carcinoma

X Cheng, Z Zeng, H Yang, Y Chen, Y Liu, X Zhou… - BMC cancer, 2023 - Springer
Background Cuproptosis, an emerging form of programmed cell death, has recently been
identified. However, the association between cuproptosis-related long non-coding RNA …

Surgery in recurrent ovarian cancer: a meta-analysis

MT Climent, A Serra, M Llueca, A Llueca - Cancers, 2023 - mdpi.com
Simple Summary Ovarian cancer has the highest mortality rate of any type of gynecological
cancer because it is diagnosed in advanced stages and its recurrence rate is about 80 …

[HTML][HTML] Targeting PARP for the optimal immunotherapy efficiency in gynecologic malignancies

T Li, X Wang, S Qin, B Chen, M Yi, J Zhou - Biomedicine & …, 2023 - Elsevier
Gynecologic cancer, which includes ovarian, cervical, endometrial, vulvar, and vaginal
cancer, is a major health concern for women all over the world. Despite the availability of …

[HTML][HTML] Overcoming therapeutic resistance in pancreatic cancer: Emerging opportunities by targeting BRCAs and p53

J Calheiros, V Corbo, L Saraiva - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Pancreatic cancer (PC) is characterized by (epi) genetic and microenvironmental alterations
that negatively impact the treatment outcomes. New targeted therapies have been pursued …

[HTML][HTML] DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: a meta-analysis and systematic review

Z Phan, CE Ford, CE Caldon - Pharmacological Research, 2023 - Elsevier
Purpose The addition of PARP inhibitors to chemotherapy has been assessed in> 80 clinical
trials across multiple malignancies, on the premise that PARP inhibitors will increase …

Mathematical modeling of the early modeled CA-125 longitudinal kinetics (KELIM-PARP) as a pragmatic indicator of rucaparib efficacy in patients with recurrent …

O Colomban, EM Swisher, R Kristeleit, I McNeish… - …, 2023 - thelancet.com
Background PARP inhibitors (PARPi) have revolutionized the management of advanced
ovarian carcinoma, and were investigated as forefront treatment in recurrent disease. The …