Magnetic resonance elastography from fundamental soft-tissue mechanics to diagnostic imaging

I Sack - Nature Reviews Physics, 2023 - nature.com
Magnetic resonance elastography (MRE) is a versatile imaging technique for mapping the
viscoelastic properties of soft biological tissues. It has been widely used to detect liver …

Mechanobiology of the brain in ageing and Alzheimer's disease

CM Hall, E Moeendarbary… - European Journal of …, 2021 - Wiley Online Library
Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

[HTML][HTML] Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties

G Bertalan, J Becker, H Tzschätzsch, A Morr… - Journal of the …, 2023 - Elsevier
Mechanical properties of brain tissue are very complex and vary with the species, region,
method, and dynamic range, and between in vivo and ex vivo measurements. To reconcile …

[HTML][HTML] Mechanical properties of murine hippocampal subregions investigated by atomic force microscopy and in vivo magnetic resonance elastography

AS Morr, M Nowicki, G Bertalan, R Vieira Silva… - Scientific Reports, 2022 - nature.com
The hippocampus is a very heterogeneous brain structure with different mechanical
properties reflecting its functional variety. In particular, adult neurogenesis in rodent …

[HTML][HTML] Contribution of tissue inflammation and blood-brain barrier disruption to brain softening in a mouse model of multiple sclerosis

RV Silva, AS Morr, S Mueller, SP Koch… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammatory processes occurring during multiple sclerosis cause disseminated
softening of brain tissue, as quantified by in vivo magnetic resonance elastography (MRE) …

[HTML][HTML] Cortical matrix remodeling as a hallmark of relapsing–remitting neuroinflammation in MR elastography and quantitative MRI

RV Silva, AS Morr, H Herthum, SP Koch, S Mueller… - Acta …, 2024 - Springer
Multiple sclerosis (MS) is a chronic neuroinflammatory disease that involves both white and
gray matter. Although gray matter damage is a major contributor to disability in MS patients …

In vivo stiffness of multiple sclerosis lesions is similar to that of normal-appearing white matter

H Herthum, S Hetzer, M Scheel, M Shahryari, J Braun… - Acta Biomaterialia, 2022 - Elsevier
Abstract In 1868, French neurologist Jean-Martin Charcot coined the term multiple sclerosis
(MS) after his observation that numerous white matter (WM) glial scars felt like sclerotic …

[HTML][HTML] Real-time multifrequency MR elastography of the human brain reveals rapid changes in viscoelasticity in response to the Valsalva maneuver

H Herthum, M Shahryari, H Tzschätzsch… - … in Bioengineering and …, 2021 - frontiersin.org
Modulation of cerebral blood flow and vascular compliance plays an important role in the
regulation of intracranial pressure (ICP) and also influences the viscoelastic properties of …

Superviscous properties of the in vivo brain at large scales

H Herthum, SCH Dempsey, A Samani, F Schrank… - Acta biomaterialia, 2021 - Elsevier
There is growing awareness that brain mechanical properties are important for neural
development and health. However, published values of brain stiffness differ by orders of …

Microscale characterisation of the time-dependent mechanical behaviour of brain white matter

A Jamal, A Bernardini, D Dini - Journal of the Mechanical Behavior of …, 2022 - Elsevier
Brain mechanics is a topic of deep interest because of the significant role of mechanical
cues in both brain function and form. Specifically, capturing the heterogeneous and …