Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disorder with the
predominant clinical manifestation of spasticity in the lower extremities. HSP is categorised …

Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

Bi-allelic loss-of-function variants in genes that encode subunits of the adaptor protein
complex 4 (AP-4) lead to prototypical yet poorly understood forms of childhood-onset and …

Molecular pathways that intrinsically regulate neuronal maintenance are poorly understood,
but rare pathogenic mutations that underlie neurodegenerative disease can offer important …

The spectrum of tauopathy encompasses heterogenous group of neurodegenerative
disorders characterized by neural or glial deposition of pathological protein tau. Clinically …

Hereditary spastic paraplegia (HSP) is characterized by progressive lower limb spasticity.
There is no disease-modifying treatment currently available. Therefore, standardized …

Hereditary spastic paraplegia (HSP) is a heterogeneous group of rare motor neuron
disorders characterized by progressive weakness and spasticity of the lower limbs. HSP …

Background Hereditary spastic paraplegia (HSP) encompasses several rare genetic
disorders characterized by progressive lower extremity spasticity and weakness caused by …

Background Spinal cord has been considered the main target of damage in hereditary
spastic paraplegias (HSPs), but mounting evidence indicates that the brain is also affected …

Abstract Objective Hereditary spastic paraplegias (HSPs) are a group of inherited
neurodegenerative disorders characterized by slowly progressive lower limb spasticity and …