Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in the first step of the
serine synthesis pathway (SSP), is overexpressed in multiple types of cancers. The …

Prostate cancer is the leading cause of cancer‑related mortality among men worldwide. In
particular, castration‑resistant prostate cancer presents a formidable clinical challenge and …

Prostate cancer (PCa) is a common malignant tumor with high morbidity and mortality
worldwide. The prostate cancer stem cell (PCSC) model provides novel insights into the …

Background and aims The tumor microenvironment (TME) has pivotal parts within multiple
tumor models of onset/progression, such as triple-negative breast cancer (TNBC). This …

Background Cell metabolism plays a pivotal role in tumor progression, and targeting cancer
metabolism might effectively kill cancer cells. We aimed to investigate the role of …

Background Prostate cancer is a leading cause of cancer-related deaths among men
worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in …

Recently, radioresistance has become a major obstacle in the radiotherapy of cervical
cancer. To demonstrate enhanced radiosensitization against radioresistant cervical cancer …

Epigenetic modifiers are upregulated during the process of prostate cancer, acquiring
resistance to castration therapy and becoming lethal metastatic castration-resistant prostate …

Simple Summary Castration-resistant prostate cancer (CRPC) treatments include next-
generation anti-androgen therapies (NGATs), taxane therapy, and PARP inhibitors (PARPi) …

Background In the context of prostate cancer (PCa), the occurrence of biochemical
recurrence (BCR) stands out as a pivotal factor significantly impacting prognosis, potentially …