High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …

Reference is regularly made to the power of new genomic sequencing approaches. Using
powerful technology, however, is not the same as having the necessary power to address a …

In recent years, high-throughput next-generation sequencing technology has allowed a
rapid increase in diagnostic capacity and precision through different bioinformatics …

Background PCR clonal artefacts originating from NGS library preparation can affect both
genomic as well as RNA-Seq applications when protocols are pushed to their limits. In RNA …

Glioblastoma (GBM), the most aggressive brain tumor, is associated with a median survival
at diagnosis of 16–20 months and limited treatment options. The key hallmark of GBM is …

Massively parallel RNA sequencing (RNA-seq) has rapidly become the assay of choice for
interrogating RNA transcript abundance and diversity. This article provides a detailed …

Since the sequence of the human genome is complete, the main issue is how to understand
the information written in the DNA sequence. Despite numerous genome-wide studies that …

Background RNA-Sequencing analysis methods are rapidly evolving, and the tool choice for
each step of one common workflow, differential expression analysis, which includes read …

Small RNA-Seq has emerged as a powerful tool in transcriptomics, gene expression
profiling and biomarker discovery. Sequencing cell-free nucleic acids, particularly microRNA …

The BTK inhibitor ibrutinib has demonstrated a remarkable therapeutic effect in mantle cell
lymphoma (MCL). However, approximately one-third of patients do not respond to the drug …