Cholangiocarcinoma (CCA) is a malignancy with features of the biliary epithelium. Although
CCA is recognized as a rare cancer, it is the second most common primary liver tumor after …

Metabolic homeostasis emerges from the complex, multidirectional crosstalk between key
metabolic tissues including adipose tissue, liver, and skeletal muscle. This crosstalk …

Extracellular communication in the tumor microenvironment is critical. Results of qRT-PCR
show that circ-0051443 is significantly lower in the plasma exosomes and tissues from …

Rationale: Ureteral obstruction-induced hydronephrosis is associated with renal fibrosis and
progressive chronic kidney disease (CKD). Exosome-mediated cell-cell communication has …

Increased vascular permeability facilitates metastasis. Emerging evidence indicates that
secreted microRNAs (miRNAs) may mediate the crosstalk between cancer and stromal cells …

Background and Aims Hepatic macrophages can be activated by many factors such as gut‐
derived bacterial components and factors released from damaged hepatocytes …

Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the
progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte …

Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but
the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis …

Extracellular vesicles (EVs) are nanometer‐sized, membrane‐bound vesicles released by
cells into the extracellular milieu. EVs are now recognized to play a critical role in cell‐to‐cell …

Impairment in macroautophagy/autophagy flux and inflammasome activation are common
characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved …