Background & Aims There is controversy over whether use of non-vitamin K antagonist oral
anticoagulants (NOACs) associates with increased risk of major gastrointestinal bleeding …

Atrial fibrillation (AF) is the most common arrhythmia conferring a fivefold increased risk of
stroke. Stroke prevention is the cornerstone of management of patients with AF. Asians have …

Background Observational studies using large claims databases for diabetes patients have
been increasingly conducted. While validation of outcomes is important in such studies …

Objective To assess the safety (ie, risk of bleeding) and effectiveness (ie, risk of
stroke/systemic embolism (SE)) separately for four non-vitamin K oral anticoagulants …

Background Whether four direct oral anticoagulants (DOACs) are superior to warfarin
among Asians with non-valvular atrial fibrillation (NVAF) remains unclear in the real-world …

The disease burden of AF is greater in Asia-Pacific than other areas of the world. Direct oral
anticoagulants (DOACs) have emerged as effective alternatives to vitamin K antagonists …

Vitamin K can be given oral, intravenously, or subcutaneous, but for patients with serious life-
threatening bleeding, it is recommended to administer 10 mg IV as it reverses coagulopathy …

The role of non-vitamin K antagonist oral anticoagulants (NOACs) in stroke prevention
remains unclear in Asian patients with atrial fibrillation (AF). Therefore, we performed a meta …

Background: There is a plethora of real-world data on the safety and effectiveness of direct-
acting oral anticoagulants (DOACs); however, study heterogeneity has contributed to …

Background The safety and effectiveness of reduced-dose apixaban 2.5 mg twice daily (BID)
have not been elucidated thoroughly in Japanese patients with nonvalvular atrial fibrillation …