Ageing is a multifactorial biological process leading to a progressive decline of physiological
functions. The process of ageing includes numerous changes in the cells and the …

Wound healing is triggered by inflammation elicited after tissue injury. Mesenchymal cells,
specifically fibroblasts, accumulate in the injured tissues, where they engage in tissue repair …

Alveolar epithelial cell (AEC) senescence is a key driver of a variety of chronic lung
diseases. It remains a challenge how to alleviate AEC senescence and mitigate disease …

Aging is a major driving factor in lung diseases. Age-related lung disease is associated with
downregulated expression of SIRT1, an NAD+-dependent deacetylase that regulates …

Adequate lung epithelial repair relies on supportive interactions within the epithelial niche,
including interactions with WNT-responsive fibroblasts. In fibroblasts from patients with …

The role and mechanisms of integrated stress response inhibitor (ISRIB) on silicosis are still
not well defined. In the present study, the effects of ISRIB on cellular senescence and …

Backgrounds Chronic obstructive pulmonary disease (COPD) is a major health issue
resulting in significant mortality worldwide. Due to the high heterogeneity and unclear …

The endoplasmic reticulum (ER) is an integral organelle for maintaining protein
homeostasis. Multiple factors can disrupt protein folding in the lumen of the ER, triggering …

Aging exhibits several hallmarks in common with cancer, such as cellular senescence,
dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades …

It is claimed that delaying aging is more effective and less expensive than treating specific
age-related disorders. Compounds that may postpone the onset of age-related symptoms …