NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Peptic ulcers are characterized by erosions on the mucosa of the gastrointestinal tract that
may reach the muscle layer. Their etiology is multifactorial and occurs when the balance …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …

Acetaminophen (APAP) is one of the safest and most effective over-the-counter (OTC)
analgesics and antipyretics, but excessive doses of APAP will induce hepatotoxicity with …

Isoorientin is a natural C-glucosyl flavone that is generating a lot of interest due to its
multiple pharmacological activities. Increasing experimental data have shown that the robust …

Obesity-induced cardiac dysfunction is a severe global disease associated with high dietary
fat intake, and its pathogenesis includes inflammation, oxidative stress, and ferroptosis …

Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds,
biological agents, and medical products. These reactions can manifest as acute or chronic …

Cisplatin (CDDP) is a widely used chemotherapeutic agent for various solid tumors, but its
severe side effects, particularly nephrotoxicity, limit its clinical application. Isoorientin (Iso) is …

Objective Acetaminophen (APAP) is one of the world's popular and safe painkillers, and
overdose can cause severe liver damage and even acute liver failure. The effect and …