The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

Periodic mesoporous organosilica as a nanoadjuvant for subunit vaccines elicits potent antigen-specific germinal center responses by activating naive B cells

F Li, X Feng, J Huang, M Zhang, W Liu, X Wang… - ACS …, 2023 - ACS Publications
Infection diseases such as AIDS and COVID-19 remain challenging in regard to protective
vaccine design, while adjuvants are critical for subunit vaccines to induce strong, broad, and …

[HTML][HTML] CD4+ T-cell subsets in autoimmune hepatitis: A review

H Chen, Z Han, Y Fan, L Chen, F Peng… - Hepatology …, 2023 - journals.lww.com
Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …

IL-22 as a target for therapeutic intervention: current knowledge on its role in various diseases

P Seth, S Dubey - Cytokine, 2023 - Elsevier
IL-22 has emerged as a crucial cytokine mediating protective response against pathogens
and tissue regeneration. Dysregulated production of IL-22 has been shown to play a pivotal …

HIV-1–host interaction in gut-associated lymphoid tissue (GALT): effects on local environment and comorbidities

S Moretti, I Schietroma, G Sberna… - International Journal of …, 2023 - mdpi.com
HIV-1 replication in the gastrointestinal (GI) tract causes severe CD4+ T-cell depletion and
disruption of the protective epithelial barrier in the intestinal mucosa, causing microbial …

Interleukin-22 and interleukin-33 show up-regulated levels in the serum of patients with mild/moderate Coronavirus disease 2019

AY Majeed, NES Zulkafli, AH Ad'hiah - Beni-Suef University Journal of …, 2023 - Springer
Background This study analyzed serum concentrations of interleukin (IL)-22 and IL-33 (pro-
inflammatory and anti-inflammatory cytokines) in 90 patients with mild/moderate coronavirus …

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19

D Martonik, A Parfieniuk-Kowerda, A Starosz… - Frontiers in …, 2023 - frontiersin.org
Background The severity of COVID-19 is associated with an elevated level of a variety of
inflammatory mediators. Increasing evidence suggests that the Th17 response contributes to …

Identification of COVID-19 severity biomarkers based on feature selection on single-cell RNA-Seq data of CD8+ T cells

J Lu, M Meng, XC Zhou, S Ding, KY Feng, Z Zeng… - Frontiers in …, 2022 - frontiersin.org
The global outbreak of the COVID-19 epidemic has become a major public health problem.
COVID-19 virus infection triggers a complex immune response. CD8+ T cells, in particular …

The correlation of Th22 and regulatory T cells with Helicobacter pylori infection in patients with chronic gastritis

B Yao, X Xu, W Liu, Q Zhang, W Wang… - Immunity, Inflammation …, 2023 - Wiley Online Library
Objective Helicobacter pylori is planted in the human stomach and is the most common
cause of chronic gastritis, which produced specific local and systemic humoral immunity …