In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

During the past century, few proteins have matched erythropoietin (Epo) in capturing the
imagination of physiologists, molecular biologists, and, more recently, physicians and …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

model of heart failure induced by myocardial infarction, anemia was linked to activation of
the TNF-/Fas signaling pathway. 34 The number of bone marrow progenitor cells and the …

Stem cell transplantation may repair the injured heart, but tissue regeneration is limited by
death of transplanted cells. Most cell death occurs in the first few days post-transplantation …

Anemia is a common comorbidity in patients with heart failure and is associated with worse
long-term outcomes. Although the cause of anemia in heart failure is unclear, the weight of …

In the haematopoietic system, the principal function of erythropoietin (Epo) is the regulation
of red blood cell production, mediated by its specific cell surface receptor (EpoR). Following …

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a devastating
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …

Objectives: We assessed the effects of erythropoietin (EPO) treatment in a rat model of post-
myocardial infarction (MI) heart failure. Background: Erythropoietin, traditionally known as a …