Building iron-sulfur (Fe-S) clusters and assembling Fe-S proteins are essential actions for
life on Earth. The three processes that sustain life, photosynthesis, nitrogen fixation, and …

While iron is essential to sustain growth, its excess can be detrimental to the cell by
generating highly toxic reactive oxygen species. Regulation of iron homeostasis thus plays a …

Queuosine (Q) is a conserved hypermodification of the wobble base of tRNA containing
GUN anticodons but the physiological consequences of Q deficiency are poorly understood …

Oxygenic photosynthesis crucially depends on proteins that possess Fe 2+ or Fe/S
complexes as co-factors or prosthetic groups. Here, we show that the small regulatory RNA …

The response to iron limitation of several bacteria is regulated by the ferric uptake regulator
(Fur). The Fur-regulated transcriptional, translational and metabolic networks of the Gram …

Iron sulfur (Fe-S) clusters rank among the most ancient and conserved prosthetic groups. Fe-
S clusters containing proteins are present in most, if not all, organisms. Fe-S clusters …

The natural product holomycin contains a unique cyclic ene–disulfide and exhibits broad-
spectrum antimicrobial activities. Reduced holomycin chelates metal ions with a high affinity …

A full understanding of the contribution of small RNAs (sRNAs) to bacterial virulence
demands knowledge of their target suites under infection-relevant conditions. Here, we take …

Phenotypic resistance describes a bacterial population that becomes transiently resistant to
an antibiotic without requiring a genetic change. We here investigated the role of the small …

Tuberculosis (TB) remains the leading cause of death due to a single pathogen, accounting
for 1.5 million deaths annually on the global level. Mycobacterium tuberculosis, the …