Pancreatic islet microcirculation, consisting of pancreatic islet microvascular endothelial
cells (IMECs) and pericytes (IMPCs), provides crucial support for the physiological function …

In most organs, blood vessels provide a continuous supply of oxygen, nutrients, and growth
factors. In the case of pancreas, such environmental signals are crucial for both the …

BACKGROUND: Pancreatic islet microvasculature is essential for optimal islet function and
glucose homeostasis. However, islet vessel pathogenesis and its role in the manifestation of …

Background: Type 1 diabetes is an autoimmune disorder characterized by the loss of
pancreatic islets. Islet allotransplantation is a potentially beneficial therapeutic approach for …

Results: The osteoclast formation assay indicated that VEGF-C resulted in 500 or 450 vs.
100 (p< 0.05) of osteoclasts in mouse bone marrow cells and RAW264. 7 cells, respectively …

Pancreatic islet transplantation is a promising clinical treatment for type 1 diabetes, but
success is limited by extensive β-cell death in the immediate posttransplant period and …

The pancreas is the key organ for the maintenance of euglycemia. This is regulated in
particular by α-cell-derived glucagon and β-cell-derived insulin, which are released in …

Pancreatic islets are central in the control of blood glucose and their dysfunction is a
hallmark of diabetes. Incomplete knowledge of islet biology currently prevents diagnostic …

Islet transplantation is a potential treatment for Type 1 diabetes but long term graft function is
suboptimal. The rich supply of intraislet endothelial cells diminishes rapidly after islet …

Ten percent to 15% of women take selective serotonin reuptake inhibitor (SSRI)
antidepressants during pregnancy. Offspring exposed to SSRIs are more likely to have low …