[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
Repositioning of anti-diabetic drugs against dementia: insight from molecular perspectives to clinical trials
KEK Mantik, S Kim, B Gu, S Moon, HB Kwak… - International journal of …, 2023 - mdpi.com
Insulin resistance as a hallmark of type 2 DM (T2DM) plays a role in dementia by promoting
pathological lesions or enhancing the vulnerability of the brain. Numerous studies related to …
pathological lesions or enhancing the vulnerability of the brain. Numerous studies related to …
[HTML][HTML] Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava… - Cell, 2021 - cell.com
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin
(PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn …
(PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn …
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN …
Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …
[HTML][HTML] Neuroimaging in frontotemporal dementia: heterogeneity and relationships with underlying neuropathology
Frontotemporal dementia encompasses a group of clinical syndromes defined
pathologically by degeneration of the frontal and temporal lobes. Historically, these …
pathologically by degeneration of the frontal and temporal lobes. Historically, these …
Advances in treatment of frontotemporal dementia
N Magrath Guimet… - The Journal of …, 2022 - Am Neuropsych Assoc
In this review, the authors explored the clinical features of frontotemporal dementia (FTD),
focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy …
focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy …
Primary progressive aphasia: a model for neurodegenerative disease
BL Tee, ML Gorno-Tempini - Current opinion in neurology, 2019 - journals.lww.com
Primary progressive aphasia: a model for neurodegenerative d... : Current Opinion in
Neurology Primary progressive aphasia: a model for neurodegenerative disease : Current …
Neurology Primary progressive aphasia: a model for neurodegenerative disease : Current …
Genetics and molecular mechanisms of frontotemporal lobar degeneration: an update and future avenues
R Ferrari, C Manzoni, J Hardy - Neurobiology of aging, 2019 - Elsevier
Frontotemporal lobar degeneration (FTLD) is the second most common form of dementia
after Alzheimer's disease. The study and the dissection of FTLD is complex due to its clinical …
after Alzheimer's disease. The study and the dissection of FTLD is complex due to its clinical …
Karyopherin abnormalities in neurodegenerative proteinopathies
T Pasha, A Zatorska, D Sharipov, B Rogelj… - Brain, 2021 - academic.oup.com
Neurodegenerative proteinopathies are characterized by progressive cell loss that is
preceded by the mislocalization and aberrant accumulation of proteins prone to …
preceded by the mislocalization and aberrant accumulation of proteins prone to …
Recent advances in the genetics of frontotemporal dementia
Abstract Purpose of Review In this review, we highlight recent advances in the human
genetics of frontotemporal dementia (FTD). In addition to providing a broad survey of genes …
genetics of frontotemporal dementia (FTD). In addition to providing a broad survey of genes …