Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

The cerebellum governs motor coordination and motor learning. Infection with external
microorganisms, such as viruses, bacteria, and fungi, induces the release and production of …

Compromised placental function or premature loss has been linked to diverse
neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a …

Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features
are at the core of the modular organization of the cerebellum. Previously, we showed that …

Patients with Rett syndrome suffer from a loss-of-function mutation of the Mecp2 gene, which
results in various symptoms including autistic traits and motor deficits. Deletion of Mecp2 in …

Abstract Mouse models of Autism Spectrum Disorder (ASD) have been interrogated using a
variety of behavioral tests in order to understand the symptoms of ASD. However, the …

Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory
formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation …

The cerebellum resembles a feedforward, three-layer network of neurons in which the
“hidden layer” consists of Purkinje cells (P-cells) and the output layer consists of deep …

The cerebellum is involved in learning of fine motor skills, yet whether presynaptic plasticity
contributes to such learning remains elusive. Here, we report that the EPAC-PKCε module …

Stress is the most common trigger among episodic neurologic disorders. In episodic ataxia
type 2 (EA2), physical or emotional stress causes episodes of severe motor dysfunction that …