Abstract Organophosphorous (OP) Nerve agents (NAs) are known as the deadliest chemical
warfare agents. They are divided into two classes of G and V agents. Most of them are liquid …

Epilepsy is a common neurological disorder characterized by an initial injury due to stroke,
traumatic brain injury, brain infection, or febrile seizures causing status epilepticus (SE). This …

Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by
efficient, quickly deployable countermeasures such as antidotes reactivating …

Organophosphorus (OP) compounds are highly toxic synthetic compounds which have been
used as pesticides and developed as warfare nerve agents. They represent a threat to both …

During more than five decades, pyridinium oximes have been developed as therapeutic
agents used in the medical treatment of poisoning with organophosphorus compounds …

The potent human toxicity of organophosphorus (OP) nerve agents calls for the development
of effective antidotes. Standard treatment for nerve agent poisoning with atropine and an …

The highly toxic organophosphorus (OP) nerve agent VX is characterized by a remarkable
biological persistence which limits the effectiveness of standard treatment with atropine and …

Innovative approach to drug design that's more likely to result in an approvable drug product
Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft …

Organophosphorus nerve agents (OPNAs), used in chemical warfare, irreversibly inhibit
essential cholinesterases (ChEs) in the cholinergic neurotransmission system. Several …

This review provides an overview of the global research leading to the large number of
compounds developed as reactivators of acetylcholinesterase inhibited by a variety of …