Exposure to nerve agents (NAs) and other organophosphates (OPs) can initiate seizures
that rapidly progress to status epilepticus (SE). While the electrographic and …

This review provides an overview of the global research leading to the large number of
compounds developed as reactivators of acetylcholinesterase inhibited by a variety of …

The nerve agents are extremely toxic organophosphates which lead to massive inhibition of
acetylcholinesterase (AChE) in both the central and peripheral nervous systems. The …

Exposure to organophosphorus compounds, such as soman (GD), cause widespread toxic
effects, sustained status epilepticus, neuropathology, and death. The A 1 adenosine …

Following inhalation exposure to organophosphorus nerve agents, symptoms rapidly
develop and severe respiratory symptoms, such as bronchorrhea and bronchoconstriction …

Organophosphate (OP) toxic compounds remain a great threat for humans because they are
used as pesticides or misused as chemical warfare nerve agents. Their mechanism of …

Soman, an organophosphorus (OP) compound, disrupts nervous system function through
inactivation of acetylcholinesterase (AChE), the enzyme that breaks down acetylcholine at …

High lethality, fast action, and simple synthesis make nerve agents (NAs) the most dreaded
chemical weapons (CWs) of mass destruction in the world. Disturbances of the autonomic …

Here, we present a brief review of brain-targeting chemical delivery systems (CDSs) and
their cyclodextrin-based formulations. It is dedicated to the memory of Marcus E. Brewster …

Acute organophosphate (OP) poisoning induces well-known signs of toxicosis related to
acetylcholinesterase (AChE) inhibition. However, the relationship between acute OP …