MicroRNAs and the regulation of fibrosis

X Jiang, E Tsitsiou, SE Herrick, MA Lindsay - The FEBS journal, 2010 - Wiley Online Library
MicroRNAs (miRNAs) are small, noncoding RNAs of 18–25 nucleotides that are generally
believed to either block the translation or induce the degradation of target mRNA. miRNAs …

Predictors and prevention of diabetic cardiomyopathy

V Chavali, SC Tyagi, PK Mishra - Diabetes, metabolic syndrome …, 2013 - Taylor & Francis
Despite our cognizance that diabetes can enhance the chances of heart failure, causes
multiorgan failure, and contributes to morbidity and mortality, it is rapidly increasing menace …

Role for miR-204 in human pulmonary arterial hypertension

A Courboulin, R Paulin, NJ Giguère… - Journal of Experimental …, 2011 - rupress.org
Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and
reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Because …

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

L Maegdefessel, JM Spin, U Raaz, SM Eken… - Nature …, 2014 - nature.com
Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most
prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of …

MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion

L Maegdefessel, J Azuma, R Toh, A Deng… - Science translational …, 2012 - science.org
Identification and treatment of abdominal aortic aneurysm (AAA) remains among the most
prominent challenges in vascular medicine. MicroRNAs are crucial regulators of …

MicroRNA‐27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes

N Akhtar, Z Rasheed, S Ramamurthy… - Arthritis & …, 2010 - Wiley Online Library
Objective Aberrant posttranscriptional regulation of matrix metalloproteinases (MMPs) by
microRNA has emerged as an important factor in human diseases. The aim of this study was …

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

L Maegdefessel, J Azuma, R Toh… - The Journal of …, 2012 - Am Soc Clin Investig
MicroRNAs (miRs) regulate gene expression at the posttranscriptional level and play crucial
roles in vascular integrity. As such, they may have a role in modifying abdominal aortic …

MiR-126 affects brain-heart interaction after cerebral ischemic stroke

J Chen, C Cui, X Yang, J Xu, P Venkat… - Translational stroke …, 2017 - Springer
Cardiovascular diseases are approximately three times higher in patients with neurological
deficits than in patients without neurological deficits. MicroRNA-126 (MiR-126) facilitates …

A unique microRNA signature associated with plaque instability in humans

F Cipollone, L Felicioni, R Sarzani, S Ucchino… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—Atherosclerotic plaque rupture is considered the most important
mechanism that underlies the onset of stroke, myocardial infarction, and sudden death …

Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice

D Zheng, J Ma, Y Yu, M Li, R Ni, G Wang, R Chen, J Li… - Diabetologia, 2015 - Springer
Aims/hypothesis MicroRNAs (miRs) have been suggested as potential therapeutic targets
for heart diseases. Inhibition of miR-195 prevents apoptosis in cardiomyocytes stimulated …