Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

Simple Summary Intracerebral hemorrhage (ICH) is a leading medical problem without
effective treatment options. The poor prognosis is attributed to the primary brain injury of the …

Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …

The 21-member connexin gene family exhibits distinct tissue expression patterns that can
cause a diverse array of over 30 inherited connexin-linked diseases ranging from deafness …

Connexins are assembled into dodecamer intercellular channels, a collection of which is
termed a gap junction, and their canonical function allowing direct exchange of ions and …

Background To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and
estimate its forecast value in patients with melanoma. Methods We measured the plasma …

Uveitis is a complex ocular inflammatory disease often accompanied by bacterial or viral
infections (infectious uveitis) or underlying autoimmune diseases (non-infectious uveitis) …

Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with
pronounced inflammation arising from the activation of a nucleotide-binding and …

Gap junctions (GJs), essential structures for cell-cell communication, are made of two
hemichannels (commonly called connexons), one on each adjacent cell. Found in almost all …

Respirable silica dust is a common hazard faced by occupational workers and prolonged
exposure to this dust can lead to pulmonary inflammation, fibrosis and, in severe cases …