Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …

The striatum plays a key role in mediating the acute and chronic effects of addictive drugs,
with drugs of abuse causing long-lasting molecular and cellular alterations in both dorsal …

Introduction It is now accepted that Parkinson's disease (PD) is not simply due to
dopaminergic dysfunction, and there is interest in developing non-dopaminergic …

Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by
degeneration of dopaminergic neurons in the substantia nigra pars compacta. Muscle …

Cardiomyocytes and vascular cells readily form, transport, and metabolize the endogenous
adenine nucleoside adenosine and act to regulate both interstitial and plasma adenosine …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

The A2A adenosine receptor (A2A‐AR) transcript and radioligand binding sites have a
distinct distribution in rat brain, restricted primarily to the striatum, nucleus accumbens and …