Monoamine neurotransmitters control basic emotions and affect major depressive disorders
Y Jiang, D Zou, Y Li, S Gu, J Dong, X Ma, S Xu… - Pharmaceuticals, 2022 - mdpi.com
Major depressive disorder (MDD) is a common and complex mental disorder, that adversely
impacts an individual's quality of life, but its diagnosis and treatment are not accurately …
impacts an individual's quality of life, but its diagnosis and treatment are not accurately …
Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities
Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
Adverse childhood experiences and severity levels of inflammation and depression from childhood to young adulthood: a longitudinal cohort study
Adverse childhood experiences (ACEs) are associated with depression and systemic
inflammation in adults. However, limited longitudinal research has tested these relationships …
inflammation in adults. However, limited longitudinal research has tested these relationships …
The immune profile of major dysmood disorder: proof of concept and mechanism using the precision nomothetic psychiatry approach
Major depressive disorder and a major depressive episode (MDD/MDE) are characterized
by activation of the immune-inflammatory response system (IRS) and the compensatory …
by activation of the immune-inflammatory response system (IRS) and the compensatory …
Neuroinflammation in autism spectrum disorders: Exercise as a “pharmacological” tool
CVA Toscano, L Barros, AB Lima, T Nunes… - Neuroscience & …, 2021 - Elsevier
The worldwide prevalence of ASD is around 1%. Although the pathogenesis of ASD is not
entirely understood, it is recognized that a combination of genetic, epigenetics …
entirely understood, it is recognized that a combination of genetic, epigenetics …
Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway
Y Fang, X Ding, Y Zhang, L Cai, Y Ge, K Ma… - Journal of …, 2022 - Springer
Background Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to
directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby …
directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby …
α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect
H Liu, X Zhang, P Shi, J Yuan, Q Jia, C Pi… - Journal of …, 2023 - Springer
Depression is a common mental illness, which is related to monoamine neurotransmitters
and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems …
and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems …
Changes in fecal microbiota composition and the cytokine expression profile in school-aged children with depression: A case-control study
Z Ling, Y Cheng, F Chen, X Yan, X Liu, L Shao… - Frontiers in …, 2022 - frontiersin.org
Depression in childhood negatively affects the growth and development, school
performance, and peer or family relationships of affected children, and may even lead to …
performance, and peer or family relationships of affected children, and may even lead to …
Role of inflammatory mechanisms in major depressive disorder: from etiology to potential pharmacological targets
BR Kouba, L de Araujo Borba, P Borges de Souza… - Cells, 2024 - mdpi.com
The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …
of major depressive disorder (MDD) has been demonstrated. The increase of pro …
Neuroinflammation in HIV-associated depression: Evidence and future perspectives
People living with HIV face a high risk of mental illness, especially depression. We do not yet
know the precise neurobiological mechanisms underlying HIV-associated depression …
know the precise neurobiological mechanisms underlying HIV-associated depression …