Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion,
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …
Astroglial Dysfunctions in Mood Disorders and Rodent Stress Models: Consequences on Behavior and Potential as Treatment Target
Astrocyte dysfunctions have been consistently observed in patients affected with depression
and other psychiatric illnesses. Although over the years our understanding of these …
and other psychiatric illnesses. Although over the years our understanding of these …
Single-Cell Sequencing Technology and Its Application in the Study of Central Nervous System Diseases
Y Ding, YY Peng, S Li, C Tang, J Gao, HY Wang… - Cell Biochemistry and …, 2023 - Springer
The mammalian central nervous system consists of a large number of cells, which contain
not only different types of neurons, but also a large number of glial cells, such as astrocytes …
not only different types of neurons, but also a large number of glial cells, such as astrocytes …
Stress, heritability, and genetic factors influencing depression, PTSD, and suicidal behavior
NH Kalin - American journal of psychiatry, 2023 - Am Psychiatric Assoc
This issue of the Journal brings together papers that further our understanding of the
influences of stress, heritability, and genetic factors mediating the development of …
influences of stress, heritability, and genetic factors mediating the development of …
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Unraveling the cell-type-specific molecular pathways of PTSD: integrating GWAS with brain genomic profiling and in vitro modeling
A Iatrou, NP Daskalakis - … : official publication of the American College …, 2024 - nature.com
Understanding the pathophysiology of stress-related disorders, like post-traumatic stress
disorder (PTSD), involves dissecting the molecular mechanisms regulated by genetic and …
disorder (PTSD), involves dissecting the molecular mechanisms regulated by genetic and …
Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts
G Xie, Y Qin, N Wu, X Han, J Li - Genes, 2024 - mdpi.com
Post-traumatic stress disorder (PTSD) is the most common psychiatric disorder after a
catastrophic event; however, the efficacious treatment options remain insufficient. Increasing …
catastrophic event; however, the efficacious treatment options remain insufficient. Increasing …
[HTML][HTML] Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence
Research has identified clinical, genomic, and neurophysiological markers associated with
suicide attempts (SA) among individuals with psychiatric illness. However, there is limited …
suicide attempts (SA) among individuals with psychiatric illness. However, there is limited …
Transcriptomic pathology of neocortical microcircuit cell types across psychiatric disorders
K Arbabi, DF Newton, H Oh, MC Davie, DA Lewis… - medRxiv, 2023 - medrxiv.org
Background: Psychiatric disorders like major depressive disorder (MDD), bipolar disorder
(BD), and schizophrenia (SCZ) are characterized by altered cognition and mood, brain …
(BD), and schizophrenia (SCZ) are characterized by altered cognition and mood, brain …