Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

CM Nievergelt, AX Maihofer, EG Atkinson, CY Chen… - Nature Genetics, 2024 - nature.com
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …

Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood

NP Daskalakis, A Iatrou, C Chatzinakos, A Jajoo… - Science, 2024 - science.org
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion,
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …

Astroglial Dysfunctions in Mood Disorders and Rodent Stress Models: Consequences on Behavior and Potential as Treatment Target

Y Bansal, SA Codeluppi, M Banasr - International Journal of Molecular …, 2024 - mdpi.com
Astrocyte dysfunctions have been consistently observed in patients affected with depression
and other psychiatric illnesses. Although over the years our understanding of these …

Single-Cell Sequencing Technology and Its Application in the Study of Central Nervous System Diseases

Y Ding, YY Peng, S Li, C Tang, J Gao, HY Wang… - Cell Biochemistry and …, 2023 - Springer
The mammalian central nervous system consists of a large number of cells, which contain
not only different types of neurons, but also a large number of glial cells, such as astrocytes …

Stress, heritability, and genetic factors influencing depression, PTSD, and suicidal behavior

NH Kalin - American journal of psychiatry, 2023 - Am Psychiatric Assoc
This issue of the Journal brings together papers that further our understanding of the
influences of stress, heritability, and genetic factors mediating the development of …

Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders

CM Nievergelt, AX Maihofer, EG Atkinson, CY Chen… - medRxiv, 2023 - medrxiv.org
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …

Unraveling the cell-type-specific molecular pathways of PTSD: integrating GWAS with brain genomic profiling and in vitro modeling

A Iatrou, NP Daskalakis - … : official publication of the American College …, 2024 - nature.com
Understanding the pathophysiology of stress-related disorders, like post-traumatic stress
disorder (PTSD), involves dissecting the molecular mechanisms regulated by genetic and …

Single-Nucleus Transcriptome Profiling from the Hippocampus of a PTSD Mouse Model and CBD-Treated Cohorts

G Xie, Y Qin, N Wu, X Han, J Li - Genes, 2024 - mdpi.com
Post-traumatic stress disorder (PTSD) is the most common psychiatric disorder after a
catastrophic event; however, the efficacious treatment options remain insufficient. Increasing …

[HTML][HTML] Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence

P Barr, Z Neale, C Chatzinakos, J Schulman… - Research …, 2023 - ncbi.nlm.nih.gov
Research has identified clinical, genomic, and neurophysiological markers associated with
suicide attempts (SA) among individuals with psychiatric illness. However, there is limited …

Transcriptomic pathology of neocortical microcircuit cell types across psychiatric disorders

K Arbabi, DF Newton, H Oh, MC Davie, DA Lewis… - medRxiv, 2023 - medrxiv.org
Background: Psychiatric disorders like major depressive disorder (MDD), bipolar disorder
(BD), and schizophrenia (SCZ) are characterized by altered cognition and mood, brain …